Anti-Human CD28, Functional Grade (Clone:CD28.2) 功能抗体 (新品)

CD28 分子靶点信息概述

• 分子名：CD28, CD28 molecule
• 基因家族：CD molecules; V-set domain containing; Ig-like cell adhesion molecule family
• 全称：T-cell-specific surface glycoprotein; CD28 antigen (Tp44)

CD28 分子靶点综述

CD28 是 45 kDa 的同源二聚体，表达于大部分胸腺细胞，在外周大部分 CD4+和 CD8+ T 细胞以及 NK细胞中低水平表达。在活化的脾细胞、肥大细胞和胸腺细胞中也有表达。CD28 是 T 细胞的共刺激分子，是 CD80 (B7-1)和 CD86 (B7-2)的配体。CD28 的信号传导可刺激 IL-2 及其受体的表达，以及 CD3 活化的 T 细胞的细胞毒性。该抗体可刺激 T 细胞和 NK 细胞增殖，并促进其分泌细胞因子。

人 Human CD28 分子靶点信息

• 分子名：CD28, CD28 molecule
• 别称：
  • CD28 antigen
  • MGC138290
  • T-cell-specific surface glycoprotein CD28
  • Tp44
• 基因序列：NCBI_Gene: 940
• 蛋白序列：UniProtKB: P10747

人 Human CD28靶点分子功能（预测）

Enables protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of mitotic nuclear division; and regulatory T cell differentiation. Located in external side of plasma membrane. Part of protein complex involved in cell adhesion. Implicated in multiple sclerosis and type 1 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); chronic fatigue syndrome; diabetic angiopathy; lung disease (multiple); and respiratory syncytial virus infectious disease.