CD28 靶点信息

CD28 分子靶点信息概述

  • 分子名：CD28, CD28 molecule
  • 基因家族：CD molecules; V-set domain containing; Ig-like cell adhesion molecule family
  • 全称：T-cell-specific surface glycoprotein; CD28 antigen (Tp44)

CD28 分子靶点综述

CD28 是 45 kDa 的同源二聚体，表达于大部分胸腺细胞，在外周大部分 CD4+和 CD8+ T 细胞以及 NK细胞中低水平表达。在活化的脾细胞、肥大细胞和胸腺细胞中也有表达。CD28 是 T 细胞的共刺激分子，是 CD80 (B7-1)和 CD86 (B7-2)的配体。CD28 的信号传导可刺激 IL-2 及其受体的表达，以及 CD3 活化的 T 细胞的细胞毒性。该抗体可刺激 T 细胞和 NK 细胞增殖，并促进其分泌细胞因子。

CD28, CD28 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD28 分子靶点信息

  • 分子名：CD28, CD28 molecule
  • 别称：
    • CD28 antigen
    • MGC138290
    • T-cell-specific surface glycoprotein CD28
    • Tp44
  • 基因序列：NCBI_Gene: 940
  • 蛋白序列：UniProtKB: P10747

人 Human CD28靶点分子功能（预测）

Enables protease binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of mitotic nuclear division; and regulatory T cell differentiation. Located in external side of plasma membrane. Part of protein complex involved in cell adhesion. Implicated in multiple sclerosis and type 1 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); chronic fatigue syndrome; diabetic angiopathy; lung disease (multiple); and respiratory syncytial virus infectious disease.

小鼠 Mouse Cd28 分子靶点信息

小鼠 Mouse Cd28 靶点分子功能（预测）

Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule).

大鼠 Rat Cd28 分子靶点信息

大鼠 Rat Cd28 靶点分子功能（预测）

Enables identical protein binding activity. Involved in T cell activation and T cell costimulation. Located in membrane raft. Used to study lymphopenia. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule).

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