Anti-Human CD117, PE(Clone：104D2) (新品)

KIT 分子靶点信息概述

• 分子名：KIT, KIT proto-oncogene, receptor tyrosine kinase
• 基因家族：Receptor tyrosine kinases; CD molecules; Immunoglobulin like domain containing
• 别名：CD117; SCFR; C-Kit
• 曾用名：PBT
• 全称：mast/stem cell growth factor receptor Kit; piebald trait; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

KIT 分子靶点综述

CD117 也称为 c-Kit、Steel 因子受体和干细胞因子受体，这种酪氨酸激酶蛋白主要表达于造血祖细胞、肥大细胞、急性髓系白血病细胞(AML)。CD117 激活促进了这些细胞亚型的增殖和分化。缺乏或缺陷干细胞因子可导致造血祖细胞数量减少和严重贫血。CD117 也由黑色素细胞表达，并在这些细胞的信号传导和激活中起作用。

人 Human KIT 分子靶点信息

• 分子名：KIT, KIT proto-oncogene, receptor tyrosine kinase
• 别称：
  • C-Kit
  • c-Kit protooncogene
  • CD117
  • KIT proto-oncogene receptor tyrosine kinase
  • mast/stem cell growth factor receptor
  • mast/stem cell growth factor receptor Kit
  • MASTC
  • p145 c-kit
  • PBT
  • piebald trait
  • piebald trait protein
  • proto-oncogene c-Kit
  • proto-oncogene tyrosine-protein kinase Kit
  • SCFR
  • soluble KIT variant 1
  • tyrosine-protein kinase Kit
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
• 基因序列：NCBI_Gene: 3815
• 蛋白序列：UniProtKB: P10721

人 Human KIT靶点分子功能（预测）

Enables cytokine binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space; fibrillar center; and plasma membrane. Implicated in several diseases, including acute myeloid leukemia; gastrointestinal stromal tumor; germ cell cancer (multiple); piebaldism; and renal cell carcinoma. Biomarker of several diseases, including Hirschsprung's disease; invasive ductal carcinoma; oxyphilic adenoma; reproductive organ cancer (multiple); and urinary system cancer (multiple).