文章目录[隐藏]
2024年6月24日，南京医科大学第二附属医院研究团队在Signal Transduction and Targeted Therapy（IF=40.8）在线发表题为“Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer”的研究论文，通过工程化细胞外囊泡（Extracellular Vesicles, EVs）实现了对肿瘤相关成纤维细胞（Cancer-Associated Fibroblasts, CAFs）的靶向重编程，并进而调控胰腺癌肿瘤微环境（Tumor Microenvironment, TME），为提高胰腺癌患者的化疗效果提供了一种全新的策略。
此论文使用了联科生物Human IL-6 ELISA kit（货号：EK106），Human/Mouse TGF-β1 ELISA kit（货号：EK981）和Human CXCL12/SDF-1 ELISA kit（货号：EK1119）3种检测试剂盒。
本研究中，研究人员发现miR-138-5p和PFD在EVs中的结合协同促进CAF重编程，并抑制CAF的促癌作用。使用原位组织丰富和患者来源异种移植小鼠模型的体外预临床实验取得了令人鼓舞的结果。特别是，IEVs-PFD/138有效地重编程了CAF并重塑了TME，从而导致肿瘤压力降低、吉西他滨渗透增强、肿瘤缺氧改善以及癌细胞对化疗的敏感性提高。
因此，本研究开发的策略可以改善化疗效果。将IEVs-PFD/138作为靶向治疗剂用于调节CAF和TME代表了治疗胰腺癌的一种有前途的治疗方法。
联科生物产品助力生命科学研究
1.A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide
2.Cd137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating Nf-Κb Pathway
产品名：Human/Mouse TGF-β1 ELISA kit
1.Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial
2.Light-Triggered Efficient Sequential Drug Delivery of Biomimetic Nanosystem for Multimodal Chemo-, Antiangiogenic, and Anti-MDSC Therapy in Melanoma
产品名：Human CXCL12/SDF-1 ELISA kit
1.Functional decellularized fibrocartilaginous matrix graft for rotator cuff enthesis regeneration: A novel technique to avoid in-vitro loading of cells
2.Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation
参考文献：
Zhou P, Du X, Jia W, Feng K, Zhang Y. Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer. Signal Transduct Target Ther. 2024 Jun 24;9(1):151. doi: 10.1038/s41392-024-01872-7.
原文链接：
https://pubmed.ncbi.nlm.nih.gov/38910148/
