肿瘤代谢——Novus脂类代谢研究系列4

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http://www.liankebio.com/article-information_Newsletter-958.html

作者：Novus官网 发布日期：2014-11-01 08:00

肿瘤细胞最重要的生物学特征是无限制的快速增殖，为了满足其快速增殖的需要，肿瘤细胞表现出与正常细胞不同的代谢特征。早在1924年Otto Warhurg就发现肿瘤细胞在葡萄糖的利用上与正常细胞不同，即肿瘤细胞更喜欢将葡萄糖进行糖酵解转变为乳酸，而不是像正常细胞那样经三羧酸循环（TCA cycle）由线粒体氧化磷酸化产生三磷酸腺苷（ATP），即使在氧气充足的情况下也是如此。最早对此现象的解释是Warburg本人于1956年提出，而后来研究者发现在大多数肿瘤细胞中线粒体的功能并未受损，说明Warburg现象是由其他原因造成的。随着人们对肿瘤研究的逐步深入，肿瘤细胞的代谢途径以及调控已经得到初步阐明。

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相关指标
• ADFP • AMACR • ARH • AS3MT • ATF6 • Cathepsin E • Caveolin 1 • CBR3 • Ceramide Kinase • CHREBP • CLPP • CPT1B1 • CYP7B1 • Cytochrome P450 • DCXR • EDG1 • EDG2 • elF2 • GADD34 • GLUT1 • Importin 13 • Lipocalin 2 • Macrophage Scavenger Recptor 1 • MafA • MafB • MARCKS • MCT2 • MRP1 • MRP4 • MTCH1 • ORP1 • OSBP • OSBP1

产品引用文献：

1.[ADFP Antibody NB110-40877] Wohlers LM, Jackson KC, Spangenburg EE. Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy. J Cell Biochem. 2011 Aug 3. [PMID: 21815195]

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4.[Cytochrome P450 17A1 Antibody NB100-92420] Jeong CW, Yoon CY, Jeong SJ, et al. Limited expression of cytochrome p450 17[alpha]-hydroxylase/17,20-lyase in prostate cancer cell lines.Korean J Urol. 2011 Jul;52(7):494-497. [PMID: 21860772]

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7.Intracellular Cholesterol Binding Proteins Enhance HDL-mediated Cholesterol Uptake in Cultured Primary Mouse Hepatocytes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2012 Jan 12.

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10.[PDK1 Antibody NB100-2384] Lin HP, Jiang SS, Chuu CP. Caffeic Acid Phenethyl Ester Causes p21 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells. PLoS One. 2012;7(2):e31286. [PMID: 22347457]联科生物代理截止时间：2017年6月30日