ZAP70 靶点信息

ZAP70 分子靶点信息概述

  • 分子名：ZAP70, zeta chain of T cell receptor associated protein kinase 70
  • 基因家族：SH2 domain containing; Syk family tyrosine kinases
  • 别名：ZAP-70; STD
  • 曾用名：SRK
  • 全称：tyrosine-protein kinase ZAP-70; SRK

ZAP70 分子靶点综述

TCR 相关蛋白-70，在 T 细胞和 NK 细胞中表达，是 TCR信号传递和发育所必需的。ZAP-70 通过与 TCR 复合物不变亚基中存在的 ITAMs 结合，与 TCR 复合物相互作用。激活后，ZAP-70通过两种机制在几个酪氨酸残基上磷酸化：自磷酸化和 Src 家族酪氨酸激酶Lck1-3的反式磷酸化。酪氨酸磷酸化 ZAP-70 与其增加激酶活性有关，并触发下游信号事件。虽然 ZAP-70 通常在T 细胞和 NK 细胞中表达，但最近的几项研究也显示 ZAP-70 阳性表达与突变 IgVH 在 B 慢性淋巴细胞白血病(CCL)中的表达高度相关。总之，ZAP-70 的表达可以通过细胞内流式细胞术来测量，可以作为 B-CLL 的预后指标。

ZAP70, zeta chain of T cell receptor associated protein kinase 70 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ZAP70 分子靶点信息

  • 分子名：ZAP70, zeta chain of T cell receptor associated protein kinase 70
  • 别称：
    • 70 kDa zeta-associated protein
    • 70 kDa zeta-chain associated protein
    • ADMIO2
    • FLJ17670
    • FLJ17679
    • IMD48
    • SRK
    • STCD
    • STD
    • syk-related tyrosine kinase
    • tyrosine-protein kinase ZAP-70
    • TZK
    • ZAP-70
    • zeta chain of T cell receptor associated protein kinase 70kDa
    • zeta chain of T-cell receptor associated protein kinase 70
    • zeta-chain (TCR) associated protein kinase 70kDa
    • zeta-chain associated protein kinase, 70kD
  • 基因序列：NCBI_Gene: 7535
  • 蛋白序列：UniProtKB: P43403

人 Human ZAP70靶点分子功能（预测）

Enables non-membrane spanning protein tyrosine kinase activity and phosphotyrosine residue binding activity. Involved in immune response and protein phosphorylation. Acts upstream of or within peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; and positive thymic T cell selection. Located in plasma membrane. Part of T cell receptor complex. Colocalizes with membrane raft. Implicated in immunodeficiency 48 and severe combined immunodeficiency.

小鼠 Mouse Zap70 分子靶点信息

小鼠 Mouse Zap70 靶点分子功能（预测）

Enables ATP binding activity; phosphotyrosine residue binding activity; and protein tyrosine kinase activity. Acts upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Located in cell-cell junction; cytosol; and immunological synapse. Is expressed in brain; gut; hemolymphoid system gland; liver; and lung epithelium. Used to study rheumatoid arthritis. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).

大鼠 Rat Zap70 分子靶点信息

  • 分子名：Zap70, zeta chain of T cell receptor associated protein kinase 70
  • 别称：
    • MGC108902
    • Srk
    • syk-related protein tyrosine kinase
    • tyrosine-protein kinase ZAP-70
    • Zap70_mapped
    • zeta-chain (TCR) associated protein kinase
    • zeta-chain (TCR) associated protein kinase 70
    • zeta-chain (TCR) associated protein kinase 70 (mapped)
    • zeta-chain (TCR) associated protein kinase 70kDa
  • 基因序列：NCBI_Gene: 301348
  • 蛋白序列：UniProtKB: A0A0R4J8U1

大鼠 Rat Zap70 靶点分子功能（预测）

Predicted to enable several functions, including ATP binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Predicted to be involved in cell differentiation; innate immune response; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including T cell selection; positive regulation of alpha-beta T cell activation; and protein phosphorylation. Predicted to be located in cell-cell junction; cytosol; and immunological synapse. Predicted to be part of T cell receptor complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to colocalize with membrane raft. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).

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