XPNPEP2 靶点信息

XPNPEP2 分子靶点信息概述

  • 分子名：XPNPEP2, X-prolyl aminopeptidase 2
  • 基因家族：Aminopeptidases; M24 metallopeptidase family
  • 全称：X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; Xaa-Pro aminopeptidase 2

XPNPEP2 分子靶点综述

膜结合的X-脯氨酰氨肽酶2，又名XPNPEP2，属于M24B肽酶家族。有研究报道XPNPEP2与氨肽酶P (APP)活性相关。XPNPEP2的C-2399A变异体与APP活性降低和AE-ACEi发生率升高有关。APP是N-端酰亚胺键专一性水解酶，这些键在一些胶原降解产物、神经肽、血管活性肽和细胞因子中是常见的。XPNPEP2的膜结合和可溶性形式已被鉴定为是2个独立的基因产物。易位会破坏XPNPEP2，它可编码水解N-端Xaa-脯氨酸键的Xaa脯氨酸氨基肽酶。在发生易位的成纤维细胞中可检测到XPNPEP2 mRNA，这表明该基因至少可部分逃避X染色体失活。XPNPEP2是卵巢功能早衰(POF)的候选基因。

XPNPEP2, X-prolyl aminopeptidase 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human XPNPEP2 分子靶点信息

  • 分子名：XPNPEP2, X-prolyl aminopeptidase 2
  • 别称：
    • AEACEI
    • aminoacylproline aminopeptidase
    • APP2
    • mAmP
    • membrane-bound aminopeptidase P
    • membrane-bound AmP
    • membrane-bound APP
    • X-Pro aminopeptidase 2
    • X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    • xaa-Pro aminopeptidase 2
  • 基因序列：NCBI_Gene: 7512
  • 蛋白序列：UniProtKB: O43895

人 Human XPNPEP2靶点分子功能（预测）

Predicted to enable aminopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. Implicated in acquired angioedema.

小鼠 Mouse Xpnpep2 分子靶点信息

小鼠 Mouse Xpnpep2 靶点分子功能（预测）

Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular exosome. Is expressed in brain; forelimb bud; large intestine; and neural retina. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2).

大鼠 Rat Xpnpep2 分子靶点信息

  • 分子名：Xpnpep2, X-prolyl aminopeptidase 2
  • 别称：
    • LOC102551432
    • mAPP
    • membrane-bound aminopeptidase P
    • membrane-bound APP
    • X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    • xaa-Pro aminopeptidase 2
    • xaa-Pro aminopeptidase 2-like
  • 基因序列：NCBI_Gene: 117522
  • 蛋白序列：UniProtKB: Q99MA2

大鼠 Rat Xpnpep2 靶点分子功能（预测）

Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular exosome. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to human XPNPEP2 (X-prolyl aminopeptidase 2).

XPNPEP2 分子产品列表

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