VTN 靶点信息

VTN 分子靶点信息概述

  • 分子名：VTN, vitronectin
  • 基因家族：Receptor ligands; Complement system regulators and receptors
  • 别名：VN
  • 全称：serum spreading factor; somatomedin B; complement S-protein; vitronectin (serum spreading factor, somatomedin B, complement S-protein)

VTN 分子靶点综述

玻连蛋白(VTN)，凝乳酶家族中的一员，丰富存在于血清、细胞外基质和骨中。它是一种分泌蛋白，以单链形式或由二硫键形成的夹状、双链形式存在。VTN包含三个结构域：N-端生长调节素B结构域、与血红素具有同源性的中心结构域和C-端结构域。VTN可促进细胞的粘附和扩散、抑制终端细胞补体途径的膜破坏作用、结合到多种丝氨酸蛋白酶抑制剂。推测其与止血、细胞迁移和恶性肿瘤有关。

VTN, vitronectin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human VTN 分子靶点信息

  • 分子名：VTN, vitronectin
  • 别称：
    • complement S-protein
    • epibolin
    • S-protein
    • serum spreading factor
    • serum-spreading factor
    • somatomedin B
    • V75
    • vitronectin (serum spreading factor, somatomedin B, complement S-protein)
    • VN
    • VNT
  • 基因序列：NCBI_Gene: 7448
  • 蛋白序列：UniProtKB: P04004

人 Human VTN靶点分子功能（预测）

Enables integrin binding activity. Involved in several processes, including endodermal cell differentiation; regulation of cellular protein metabolic process; and smooth muscle cell-matrix adhesion. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Biomarker of coronary artery disease and diabetic retinopathy.

小鼠 Mouse Vtn 分子靶点信息

小鼠 Mouse Vtn 靶点分子功能（预测）

Enables extracellular matrix binding activity. Involved in oligodendrocyte differentiation. Acts upstream of or within cell-matrix adhesion; extracellular matrix organization; and positive regulation of cell-substrate adhesion. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and retina. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).

大鼠 Rat Vtn 分子靶点信息

大鼠 Rat Vtn 靶点分子功能（预测）

Enables collagen binding activity; heparin binding activity; and identical protein binding activity. Involved in liver regeneration and protein polymerization. Located in several cellular components, including Golgi lumen; basement membrane; and rough endoplasmic reticulum lumen. Used to study proteinuria. Biomarker of diabetic retinopathy and visual epilepsy. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin).

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