VEGFC 靶点信息

VEGFC 分子靶点信息概述

  • 分子名：VEGFC, vascular endothelial growth factor C
  • 基因家族：VEGF family
  • 别名：VRP; VEGF-C
  • 全称：vascular endothelial growth factor-related protein

VEGFC 分子靶点综述

血管内皮生长因子C(VEGF-C)是一种二聚体分泌型蛋白，PDGF/VEGF家族中的一员。翻译后的VEGF-C有三个结构域：中间的VEGF同源结构域(VHD)、N端结构域(前肽)和C端结构域(前肽)。VEGF-C对淋巴管的生成有重要作用，主要通过结合它的受体VEGFR-3来作用于淋巴管内皮细胞，从而促进其生存、生长和迁移。研究证明，VEGF-C是各种模型淋巴管的特定生长因子。VEGF-C除了对淋巴管有作用，它还可促进血管的生长并调节血管的通透性，是通过结合它的主要受体VEGFR-3或次级受体VEGFR-2来发挥作用的。另外，VEGF-C对神经发育和血压调节也具有重要作用。缺乏VEGF-C会导致淋巴水肿，而过量的VEGF-C与肿瘤血管生成和转移有关。

VEGFC, vascular endothelial growth factor C 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human VEGFC 分子靶点信息

  • 分子名：VEGFC, vascular endothelial growth factor C
  • 别称：
    • FLT4 ligand DHM
    • Flt4-L
    • LMPH1D
    • LMPHM4
    • vascular endothelial growth factor-related protein
    • VEGF-C
    • VRP
  • 基因序列：NCBI_Gene: 7424
  • 蛋白序列：UniProtKB: P49767

人 Human VEGFC靶点分子功能（预测）

Enables chemoattractant activity and vascular endothelial growth factor receptor 3 binding activity. Involved in induction of positive chemotaxis; positive regulation of mast cell chemotaxis; and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in extracellular region and platelet alpha granule lumen. Predicted to be active in extracellular space. Implicated in breast carcinoma and hereditary lymphedema ID. Biomarker of several diseases, including invasive ductal carcinoma; liver disease (multiple); papillary carcinoma; pterygium; and urinary system cancer (multiple).

小鼠 Mouse Vegfc 分子靶点信息

  • 分子名：Vegfc, vascular endothelial growth factor C
  • 别称：
    • AW228853
    • expressed sequence AW228853
    • VEGF-C
  • 基因序列：NCBI_Gene: 22341
  • 蛋白序列：

小鼠 Mouse Vegfc 靶点分子功能（预测）

Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of angiogenesis; and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lymphangiogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).

大鼠 Rat Vegfc 分子靶点信息

  • 分子名：Vegfc, vascular endothelial growth factor C
  • 别称：
    • flt4 ligand
    • flt4-L
    • vascular endothelial growth factor-related protein
    • VEGF-C
    • VRP
  • 基因序列：NCBI_Gene: 114111
  • 蛋白序列：UniProtKB: O35757

大鼠 Rat Vegfc 靶点分子功能（预测）

Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including positive regulation of blood vessel endothelial cell migration; positive regulation of protein autophosphorylation; and regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within positive regulation of neuroblast proliferation. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of colon adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).

VEGFC 分子产品列表

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