TNNI3 靶点信息

TNNI3 分子靶点信息概述

  • 分子名：TNNI3, troponin I3, cardiac type
  • 基因家族：Troponin complex subunits
  • 别名：TNNC1, CMH7, cTNI
  • 曾用名：CMD2A
  • 全称：cardiomyopathy, dilated 2A (autosomal recessive); troponin I type 3 (cardiac); troponin I type 3

TNNI3 分子靶点综述

肌钙蛋白 I (cTnI)，也称为生长调节素 C，是一个在分子结构上类似于胰岛素的激素。cTnI 主要由肝脏产生，作为内分泌激素。同样地，靶组织亦能旁分泌/自分泌产生 cTnI。cTnI 是 AKT 信号转导途径中的一种有效天然激活剂、细胞生长和增殖的刺激子、细胞程序性死亡的有效抑制子。cTnI 最少可结合两种细胞表面受体：cTnI 受体 (IGF1R) 和胰岛素受体。cTnI 的产生受生长激素刺激，受营养不良、生长激素不敏感、缺少生长激素受体或者生长激素受体 (SHP2 和 STAT5B) 下游信号通路发生故障等方面所抑制。cTnI 在儿童生长过程中起重要作用，继而在成人合成代谢中有影响，且与老年化、神经病变、癌症以及中风相关。

TNNI3, troponin I3, cardiac type 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNNI3 分子靶点信息

  • 分子名：TNNI3, troponin I3, cardiac type
  • 别称：
    • cardiac troponin I
    • cardiomyopathy, dilated 2A (autosomal recessive)
    • CMD1FF
    • CMD2A
    • CMH7
    • cTnI
    • familial hypertrophic cardiomyopathy 7
    • MGC116817
    • RCM1
    • TNNC1
    • troponin 1, type 3
    • troponin I type 3 (cardiac)
    • troponin I, cardiac muscle
  • 基因序列：NCBI_Gene: 7137
  • 蛋白序列：UniProtKB: P19429

人 Human Tnni3靶点分子功能（预测）

Enables several functions, including calcium channel inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Involved in cardiac muscle contraction; regulation of cardiac muscle contraction by calcium ion signaling; and ventricular cardiac muscle tissue morphogenesis. Located in cardiac myofibril. Part of cardiac Troponin complex. Implicated in intrinsic cardiomyopathy (multiple). Biomarker of coronary artery disease.

小鼠 Mouse Tnni3 分子靶点信息

小鼠 Mouse Tnni3 靶点分子功能（预测）

Predicted to enable several functions, including calcium channel inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Acts upstream of or within several processes, including circulatory system development; intracellular calcium ion homeostasis; and regulation of systemic arterial blood pressure by ischemic conditions. Located in sarcomere. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and sensory organ. Used to study hypertrophic cardiomyopathy 7 and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type).

大鼠 Rat Tnni3 分子靶点信息

  • 分子名：Tnni3, troponin I3, cardiac type
  • 别称：
    • cardiac troponin I
    • cTNI
    • TnI
    • troponin 1, type 3
    • Troponin I
    • troponin I cardiac
    • troponin I type 3 (cardiac)
    • troponin I, cardiac
    • troponin I, cardiac muscle
  • 基因序列：NCBI_Gene: 29248
  • 蛋白序列：UniprotKB: P23693

大鼠 Rat Tnni3 靶点分子功能（预测）

Predicted to enable several functions, including calcium channel inhibitor activity; calcium-dependent protein binding activity; and cytoskeletal protein binding activity. Involved in cardiac muscle contraction and regulation of smooth muscle contraction. Located in sarcomere. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNI3 (troponin I3, cardiac type).

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