TNFSF15 靶点信息

TNFSF15 分子靶点信息概述

  • 分子名：TNFSF15, TNF superfamily member 15
  • 基因家族：Tumor necrosis factor superfamily
  • 别名：TL1; VEGI; TL1A; VEGI192A; MGC129934; MGC129935
  • 全称：vascular endothelial cell growth inhibitor; TNF superfamily ligand TL1A; TNF ligand-related molecule 1; vascular endothelial growth inhibitor-192A; tumor necrosis factor (ligand) superfamily, member 15

TNFSF15 分子靶点综述

肿瘤坏死因子–样配体1A (TL1A)，也叫TNFSF15，是TNF超级家族的成员。它是由位于9号染色体上9q32位点的TNFSF15基因表达的一个251个氨基酸组成的同源三聚体细胞因子。这种蛋白的表达是由TNF和IL-1α诱导的，它在内皮细胞中大量表达，但在B或T细胞中没有表达。这种细胞因子是TNFRSF25受体和TNFRSF21/DR6诱捕受体的配体。它能激活NF-kappaB和MAP激酶，也能作为自分泌因子诱导血管内皮细胞凋亡。这种细胞因子也能抑制内皮细胞的增殖，因此可能起血管生成抑制剂的作用。

TNFSF15, TNF superfamily member 15 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFSF15 分子靶点信息

  • 分子名：TNFSF15, TNF superfamily member 15
  • 别称：
    • MGC129934
    • MGC129935
    • TL1
    • TL1A
    • TNF ligand-related molecule 1
    • TNF superfamily ligand TL1A
    • TNLG1B
    • tumor necrosis factor (ligand) superfamily member 15
    • tumor necrosis factor (ligand) superfamily, member 15
    • tumor necrosis factor ligand 1B
    • tumor necrosis factor ligand superfamily member 15
    • tumor necrosis factor superfamily member 15
    • vascular endothelial cell growth inhibitor
    • vascular endothelial growth inhibitor-192A
    • VEGI
    • VEGI192A
  • 基因序列：NCBI_Gene: 9966
  • 蛋白序列：UniProtKB: O95150

人 Human TNFSF15靶点分子功能（预测）

Predicted to enable signaling receptor binding activity. Acts upstream of or within activation of NF-kappaB-inducing kinase activity and activation of cysteine-type endopeptidase activity involved in apoptotic process. Located in plasma membrane.

小鼠 Mouse Tnfsf15 分子靶点信息

小鼠 Mouse Tnfsf15 靶点分子功能（预测）

Predicted to enable death receptor binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of cytokine production. Predicted to act upstream of or within activation of NF-kappaB-inducing kinase activity. Predicted to be located in plasma membrane. Used to study inflammatory bowel disease 16. Orthologous to human TNFSF15 (TNF superfamily member 15).

大鼠 Rat Tnfsf15 分子靶点信息

  • 分子名：Tnfsf15, TNF superfamily member 15
  • 别称：
    • TNF ligand-related molecule 1
    • Tnlg1b
    • tumor necrosis factor (ligand) superfamily, member 15
    • tumor necrosis factor ligand 1b
    • tumor necrosis factor ligand superfamily member 15
    • tumor necrosis factor superfamily member 15
    • vascular endothelial cell growth inhibitor
  • 基因序列：NCBI_Gene: 252878
  • 蛋白序列：

大鼠 Rat Tnfsf15 靶点分子功能（预测）

Enables death receptor binding activity. Involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of cytokine production. Predicted to be located in plasma membrane. Orthologous to human TNFSF15 (TNF superfamily member 15).

TNFSF15 分子产品列表

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