TNFSF10 靶点信息

TNFSF10 分子靶点信息概述

  • 分子名：TNFSF10, TNF superfamily member 10
  • 基因家族：CD molecules; Tumor necrosis factor superfamily
  • 别名：TRAIL; Apo-2L; TL2; CD253
  • 全称：tumor necrosis factor (ligand) superfamily, member 10

TNFSF10 分子靶点综述

肿瘤坏死因子相关的凋亡诱导配体(TRAIL)也称为CD253或TNFSF10，可由大部分正常组织细胞产生并分泌。TRAIL与死亡受体DR4(TRAIL-RI)和DR5(TRAIL-RII)结合。凋亡的过程依赖于caspase-8。Caspase-8活化下游的caspase，包括procaspase-3、6和7，使特异性的激酶活化。TRAIL也能与不含胞浆区的受体DcR1和含有截短的死亡结构域的受体DcR2结合。DcR1可作为TRAIL中和受体。DcR2的胞浆区具有功能，可活化NF-κB。因此在表达DcR2的细胞中，TRAIL的结合会活化NF-κB，使拮抗死亡信号通路和/或促进炎症的基因发生转录。

TNFSF10, TNF superfamily member 10 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFSF10 分子靶点信息

  • 分子名：TNFSF10, TNF superfamily member 10
  • 别称：
    • Apo-2 ligand
    • Apo-2L
    • APO2L
    • CD253
    • chemokine tumor necrosis factor ligand superfamily member 10
    • TL2
    • TNF-related apoptosis inducing ligand TRAIL
    • TNF-related apoptosis-inducing ligand
    • TNLG6A
    • TRAIL
    • tumor necrosis factor (ligand) family, member 10
    • tumor necrosis factor (ligand) superfamily member 10
    • tumor necrosis factor (ligand) superfamily, member 10
    • tumor necrosis factor apoptosis-inducing ligand splice variant delta
    • tumor necrosis factor ligand 6A
    • tumor necrosis factor ligand superfamily member 10
    • tumor necrosis factor superfamily member 10
  • 基因序列：NCBI_Gene: 8743
  • 蛋白序列：UniProtKB: P50591

人 Human TNFSF10靶点分子功能（预测）

Enables identical protein binding activity and zinc ion binding activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; and positive regulation of signal transduction. Located in extracellular exosome. Implicated in arteriosclerosis and small cell carcinoma. Biomarker of type 1 diabetes mellitus.

小鼠 Mouse Tnfsf10 分子靶点信息

小鼠 Mouse Tnfsf10 靶点分子功能（预测）

Enables TRAIL binding activity and tumor necrosis factor receptor superfamily binding activity. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and plasma membrane. Predicted to be integral component of membrane. Is expressed in central nervous system; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10).

大鼠 Rat Tnfsf10 分子靶点信息

  • 分子名：Tnfsf10, TNF superfamily member 10
  • 别称：
    • 4-1BB
    • LOC500590
    • MGC114552
    • similar to T-cell antigen 4-1BB precursor - mouse
    • tumor necrosis factor receptor superfamily member 9
    • tumor necrosis factor receptor superfamily, member 9
  • 基因序列：NCBI_Gene: 246775
  • 蛋白序列：UniProtKB: E9PU84

大鼠 Rat Tnfsf10 靶点分子功能（预测）

Predicted to enable cytokine binding activity; identical protein binding activity; and signaling receptor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within negative regulation of interleukin-10 production and negative regulation of interleukin-12 production. Predicted to be located in extracellular space and plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).

TNFSF10 分子产品列表

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