TNFRSF1B 靶点信息

TNFRSF1B 分子靶点信息概述

  • 分子名：TNFRSF1B, TNF receptor superfamily member 1B
  • 基因家族：CD molecules; Tumor necrosis factor receptor superfamily; MicroRNA protein coding host genes
  • 别名：TNFBR; TNFR80; TNF-R75; TNF-R-II; p75; CD120b
  • 曾用名：TNFR2
  • 全称：tumor necrosis factor receptor superfamily, member 1B

TNFRSF1B 分子靶点综述

肿瘤坏死因子受体II (TNF RII)也称为肿瘤坏死因子受体超家族成员1B (TNFRSF1B)。该蛋白与TNF RI形成异源复合物，介导两种具有E3泛素连接酶活性的抗凋亡蛋白c-IAP1和c-IAP2的招募。IAPs在TNF受体信号传导中的功能尚未知，然而c-IAP1被认为通过泛素化和降解介导抗凋亡信号的TNF受体相关因子2 (TRAF2)来增强TNF诱导的凋亡。小鼠的基因敲除实验表明，该蛋白通过刺激抗氧化通路来保护神经元不发生凋亡的过程中发挥了作用。

TNFRSF1B, TNF receptor superfamily member 1B 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TNFRSF1B 分子靶点信息

  • 分子名：TNFRSF1B, TNF receptor superfamily member 1B
  • 别称：
    • CD120b
    • p75
    • p75 TNF receptor
    • p75TNFR
    • p80 TNF-alpha receptor
    • soluble TNFR1B variant 1
    • TBPII
    • TNF-R-II
    • TNF-R2
    • TNF-R75
    • TNF-RII
    • TNFBR
    • TNFR-II
    • TNFR1B
    • TNFR2
    • TNFR80
    • tumor necrosis factor beta receptor
    • tumor necrosis factor binding protein 2
    • tumor necrosis factor receptor 2
    • tumor necrosis factor receptor superfamily member 1B
    • tumor necrosis factor receptor superfamily, member 1B
    • tumor necrosis factor receptor type II
  • 基因序列：NCBI_Gene: 7133
  • 蛋白序列：UniProtKB: P20333

人 Human TNFRSF1B靶点分子功能（预测）

Enables tumor necrosis factor binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to lipopolysaccharide and positive regulation of membrane protein ectodomain proteolysis. Located in membrane raft. Implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Biomarker of several diseases, including autoimmune disease of musculoskeletal system (multiple); female reproductive organ cancer (multiple); glomerulonephritis (multiple); kidney failure (multiple); and lung disease (multiple).

小鼠 Mouse Tnfrsf1b 分子靶点信息

小鼠 Mouse Tnfrsf1b 靶点分子功能（预测）

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of extracellular matrix constituent secretion; regulation of nervous system development; and semi-lunar valve development. Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including blood; dorsal aorta; extraembryonic component; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B).

大鼠 Rat Tnfrsf1b 分子靶点信息

  • 分子名：Tnfrsf1b, TNF receptor superfamily member 1B
  • 别称：
    • p75
    • p80 TNF-alpha receptor
    • TNF-R2
    • TNF-RII
    • TNFR-II
    • Tnfr2
    • tumor necrosis factor receptor 2
    • tumor necrosis factor receptor superfamily member 1B
    • tumor necrosis factor receptor superfamily, member 1b
    • tumor necrosis factor receptor type II
  • 基因序列：NCBI_Gene: 156767
  • 蛋白序列：UniProtKB: Q80WY6

大鼠 Rat Tnfrsf1b 靶点分子功能（预测）

Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and varicosity. Used to study visual epilepsy. Biomarker of Crohn's disease; myocardial infarction; sciatic neuropathy; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B).

TNFRSF1B 分子产品列表

TNFRSF1B 分子靶点最新资讯

ELISA系列丨肿瘤坏死因子TNF配体及受体超家族成员