TIMP4 靶点信息

TIMP4 分子靶点信息概述

  • 分子名：TIMP4, TIMP metallopeptidase inhibitor 4
  • 基因家族：Tissue inhibitor of metallopeptidases
  • 全称：tissue inhibitor of metalloproteinase 4

TIMP4 分子靶点综述

在人类中，组织金属蛋白酶抑制因子4 (TIMP-4)是由组织金属蛋白酶抑制剂家族中的TIMP4基因编码的一种蛋白质。该家族有四个成员，TIMP-1、TIMP-2、TIMP-3和TIMP-4。在TIMP家族的四个已知成员中，TIMP-4具有所有TIMPs的共同特征和自身独特的特征。与TIMP-2不同，TIMP-4不通过活化的MMP-14(MT1-MMP)促进MMP-2前体的激活。TIMP-4 mRNA在心脏中高水平表达，在肾脏、胰腺、结肠和睾丸中表达水平较低。TIMP-4在乳腺癌、宫颈癌、子宫内膜癌、神经胶质瘤和绒毛膜癌等多种癌症中均有表达。

TIMP4, TIMP metallopeptidase inhibitor 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TIMP4 分子靶点信息

  • 分子名：TIMP4, TIMP metallopeptidase inhibitor 4
  • 别称：
    • metalloproteinase inhibitor 4
    • TIMP-4
    • tissue inhibitor of metalloproteinase 4
    • tissue inhibitor of metalloproteinases 4
  • 基因序列：NCBI_Gene: 7079
  • 蛋白序列：UniProtKB: Q99727

人 Human TIMP4靶点分子功能（预测）

Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. Predicted to be active in extracellular matrix and extracellular space. Implicated in nephroblastoma. Biomarker of ductal carcinoma in situ; female reproductive organ cancer (multiple); prostate carcinoma in situ; and renal cell carcinoma.

小鼠 Mouse Timp4 分子靶点信息

小鼠 Mouse Timp4 靶点分子功能（预测）

Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain ventricular layer; heart; ovary; skin; and ventral grey horn. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).

大鼠 Rat Timp4 分子靶点信息

  • 分子名：Timp4, TIMP metallopeptidase inhibitor 4
  • 别称：
    • LOC680130
    • metalloproteinase inhibitor 4
    • similar to Metalloproteinase inhibitor 4 precursor (TIMP-4) (Tissue inhibitor of metalloproteinases-4)
    • TIMP-4
    • Timp4_mapped
    • tissue inhibitor of metalloproteinase 4
    • tissue inhibitor of metalloproteinase 4 (mapped)
    • tissue inhibitor of metalloproteinases 4
  • 基因序列：NCBI_Gene: 680130
  • 蛋白序列：UniProtKB: P81556

大鼠 Rat Timp4 靶点分子功能（预测）

Predicted to enable metalloendopeptidase inhibitor activity; protease binding activity; and zinc ion binding activity. Involved in several processes, including ovulation cycle; response to lipopolysaccharide; and response to peptide hormone. Located in extracellular space and sarcomere. Biomarker of abdominal aortic aneurysm; congestive heart failure; and renal hypertension. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).

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