TIMP1 靶点信息

TIMP1 分子靶点信息概述

  • 分子名：TIMP1, TIMP metallopeptidase inhibitor 1
  • 基因家族：Tissue inhibitor of metallopeptidases
  • 别名：EPO
  • 曾用名：TIMP; CLGI
  • 全称：tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)

TIMP1 分子靶点综述

基质金属蛋白酶抑制剂-1(TIMP-1)是一种在生物体多种组织中表达的糖蛋白，是TIMP家族中的一员。TIMP-1是一种天然的基质金属蛋白酶(MMPs)抑制剂，后者是参与细胞外基质降解的一组肽酶。TIMP-1除了可抑制大多数已知的MMPs外，还可促进多种细胞类型的细胞繁殖，也可能具有抗凋亡作用。对许多细胞因子和激素的应答可强烈诱导该基因的转录。研究表明，人类女性中的TIMP-1基因失活是多态性的。肾上腺皮质细胞的营养激素ACTH诱导TIMP-1的表达，且TIMP表达的增加与胶原酶活性的降低有关。另外，TIMP-1表达的增加与多种肿瘤如喉癌或黑色素瘤的预后较差有关。

TIMP1, TIMP metallopeptidase inhibitor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TIMP1 分子靶点信息

  • 分子名：TIMP1, TIMP metallopeptidase inhibitor 1
  • 别称：
    • CLGI
    • collagenase inhibitor
    • EPA
    • EPO
    • erythroid potentiating activity
    • erythroid-potentiating activity
    • fibroblast collagenase inhibitor
    • FLJ90373
    • HCI
    • metalloproteinase inhibitor 1
    • TIMP
    • TIMP-1
    • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
    • tissue inhibitor of metalloproteinases 1
  • 基因序列：NCBI_Gene: 7076
  • 蛋白序列：UniProtKB: P01033

人 Human TIMP1靶点分子功能（预测）

Enables cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Involved in several processes, including cellular response to UV-A; negative regulation of proteolysis; and negative regulation of trophoblast cell migration. Located in extracellular space. Biomarker of several diseases, including CAKUT2; Down syndrome; artery disease (multiple); carcinoma (multiple); and diabetes mellitus (multiple).

小鼠 Mouse Timp1 分子靶点信息

小鼠 Mouse Timp1 靶点分子功能（预测）

Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including early conceptus; hindlimb cartilage condensation; jaw; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1).

大鼠 Rat Timp1 分子靶点信息

  • 分子名：Timp1, TIMP metallopeptidase inhibitor 1
  • 别称：
    • metalloproteinase inhibitor 1
    • Timp
    • TIMP-1
    • tissue inhibitor of metallopeptidase 1
    • tissue inhibitor of metalloproteinase 1
    • tissue inhibitor of metalloproteinases 1
  • 基因序列：NCBI_Gene: 116510
  • 蛋白序列：UniProtKB: P30120

大鼠 Rat Timp1 靶点分子功能（预测）

Enables protease binding activity. Involved in several processes, including cartilage development; response to peptide hormone; and wound healing. Located in basement membrane. Used to study degenerative disc disease. Biomarker of cholestasis; gastric ulcer; heart disease (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1).

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