TIGIT 靶点信息

TIGIT 分子靶点信息概述

  • 分子名：TIGIT, T cell immunoreceptor with Ig and ITIM domains
  • 基因家族：V-set domain containing
  • 别名：FLJ39873; DKFZp667A205
  • 曾用名：VSIG9; VSTM3
  • 全称：VSIG9, VSTM3

TIGIT 分子靶点综述

TIGIT，全称为T细胞免疫球蛋白和ITIM结构域蛋白，又称Vsig9、Vstm3或WUCAM，是脊髓灰质炎病毒受体(PVR)/Nectin家族的成员，也是免疫球蛋白超家族的成员之一。由细胞外的免疫球蛋白(IgV)结构域，I型跨膜结构域和细胞内的ITIM及免疫球蛋白酪氨酸尾(ITT)基序结构共同组成。TIGIT仅限于在淋巴细胞上表达，其中表达最多的为CD4+的调节T细胞，CD4+的滤泡辅助性T细胞，CD8+的效应T细胞和自然杀伤(NK)细胞。

TIGIT, T cell immunoreceptor with Ig and ITIM domains 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TIGIT 分子靶点信息

  • 分子名：TIGIT, T cell immunoreceptor with Ig and ITIM domains
  • 别称：
    • DKFZp667A205
    • FLJ39873
    • T-cell immunoreceptor with Ig and ITIM domains
    • V-set and immunoglobulin domain containing 9
    • V-set and immunoglobulin domain-containing protein 9
    • V-set and transmembrane domain containing 3
    • V-set and transmembrane domain-containing protein 3
    • VSIG9
    • VSIG9, VSTM3
    • VSTM3
    • Washington University cell adhesion molecule
    • WUCAM
  • 基因序列：NCBI_Gene: 201633
  • 蛋白序列：UniProtKB: Q495A1

人 Human TIGIT靶点分子功能（预测）

Enables identical protein binding activity and signaling receptor binding activity. Involved in negative regulation of interleukin-12 production and positive regulation of interleukin-10 production. Acts upstream of or within negative regulation of T cell activation. Located in cell surface.

小鼠 Mouse Tigit 分子靶点信息

小鼠 Mouse Tigit 靶点分子功能（预测）

Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).

大鼠 Rat Tigit 分子靶点信息

  • 分子名：Tigit, T cell immunoreceptor with Ig and ITIM domains
  • 别称：
    • LOC363784
    • RGD1563191
    • similar to hypothetical protein
    • T-cell immunoreceptor with Ig and ITIM domains
  • 基因序列：NCBI_Gene: 363784
  • 蛋白序列：UniProtKB: D3ZTQ2

大鼠 Rat Tigit 靶点分子功能（预测）

Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in negative regulation of T cell activation; negative regulation of interleukin-12 production; and positive regulation of interleukin-10 production. Predicted to be integral component of membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains).

TIGIT 分子产品列表

TIGIT 分子靶点最新资讯

免疫检查点Immune checkpoints —抗体和蛋白