TIE1 靶点信息

TIE1 分子靶点信息概述

  • 分子名：TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
  • 基因家族：Receptor tyrosine kinases; Fibronectin type III domain containing; Immunoglobulin like domain containing
  • 别名：JTK14
  • 曾用名：TIE
  • 全称：tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1

TIE1 分子靶点综述

酪氨酸蛋白激酶受体Tie1是一个单次跨膜的I型膜蛋白，属于蛋白激酶超家族、酪氨酸蛋白激酶家族和Tie亚家族。Tie1有三个EGF样结构域、三个纤连蛋白III型结构域、两个免疫球蛋白样C2型结构域和一个蛋白激酶结构域。Tie1是一个专门在内皮细胞中表达的细胞表面蛋白，然而，研究表明它同样也可在不成熟的造血细胞和血小板中表达。在血管发育的毛细管涌现阶段，Tie1对于微血管内皮细胞的存活和生长是必需的。Tie1通过p38依赖性机制上调细胞粘附分子VCAM-1、E-selectin和ICAM-1。Tie1的表达可增强单核细胞来源的免疫细胞粘附于内皮细胞。Tie1具有促炎症性效果，在内皮的炎症性疾病如动脉粥样硬化中起重要作用。

TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TIE1 分子靶点信息

  • 分子名：TIE1, tyrosine kinase with immunoglobulin like and EGF like domains 1
  • 别称：
    • JTK14
    • LMPHM11
    • receptor tyrosine kinase
    • soluble TIE1 variant 1
    • soluble TIE1 variant 2
    • soluble TIE1 variant 3
    • soluble TIE1 variant 4
    • soluble TIE1 variant 5
    • TIE
    • tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
    • tyrosine kinase with immunoglobulin-like and EGF-like domains 1
    • tyrosine-protein kinase receptor Tie-1
  • 基因序列：NCBI_Gene: 7075
  • 蛋白序列：UniProtKB: P35590

人 Human TIE1靶点分子功能（预测）

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of angiogenesis; and positive regulation of kinase activity. Predicted to act upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Implicated in hereditary lymphedema.

小鼠 Mouse Tie1 分子靶点信息

小鼠 Mouse Tie1 靶点分子功能（预测）

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in circulatory system development; response to retinoic acid; and tissue remodeling. Acts upstream of or within several processes, including negative regulation of angiogenesis; plasma membrane fusion; and vasculature development. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).

大鼠 Rat Tie1 分子靶点信息

  • 分子名：Tie1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1
  • 别称：
    • tyrosine kinase receptor 1
    • tyrosine-protein kinase receptor Tie-1
  • 基因序列：NCBI_Gene: 89806
  • 蛋白序列：UniProtKB: B5DFD6

大鼠 Rat Tie1 靶点分子功能（预测）

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in vasculogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1).

TIE1 分子产品列表

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