THPO 靶点信息

THPO 分子靶点信息概述

  • 分子名：THPO, thrombopoietin
  • 基因家族：Receptor ligands
  • 别名：MGDF; TPO; MPLLG

THPO 分子靶点综述

促血小板生成素(TPO)也称为巨核细胞生长发育因子(MGDF)，是由肝脏实质细胞、肝窦内皮细胞和肾小管细胞产生的糖蛋白激素。横纹肌和骨髓基质细胞也有少量表达。它可刺激巨核细胞分泌和分化形成大量血小板。正常和病理状态下均可测到循环的TPO，包括特发性血小板减少性紫癜(ITP)、特发性血小板增多症(ET)、肝硬化、无巨核细胞性血小板减少症(AMT)和再生障碍性贫血(AA)。巨核细胞数量调控可TPO水平，而血小板可调控血浆TPO水平，血小板数量和血液TPO水平之间看似没有直接关联。

THPO, thrombopoietin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human THPO 分子靶点信息

  • 分子名：THPO, thrombopoietin
  • 别称：
    • c-mpl ligand
    • megakaryocyte colony-stimulating factor
    • megakaryocyte growth and development factor
    • megakaryocyte stimulating factor
    • MGC163194
    • MGDF
    • MKCSF
    • ML
    • MPL ligand
    • MPLLG
    • myeloproliferative leukemia virus oncogene ligand
    • prepro-thrombopoietin
    • THCYT1
    • thrombopoietin nirs variant 1
    • TPO
  • 基因序列：NCBI_Gene: 7066
  • 蛋白序列：UniProtKB: P40225

人 Human TPO靶点分子功能（预测）

Predicted to enable signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; megakaryocyte development; and positive regulation of intracellular signal transduction. Acts upstream of or within positive regulation of hematopoietic stem cell proliferation. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Implicated in aplastic anemia; essential thrombocythemia; and thrombocytosis. Biomarker of arteriosclerosis obliterans; essential thrombocythemia; liver cirrhosis; pulmonary hypertension; and toxic shock syndrome.

小鼠 Mouse Thpo 分子靶点信息

小鼠 Mouse Thpo 靶点分子功能（预测）

Predicted to enable signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of megakaryocyte differentiation; and thrombopoietin-mediated signaling pathway. Acts upstream of or within myeloid cell differentiation. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including brain; dorsal aorta; gut; olfactory epithelium; and reproductive system. Human ortholog(s) of this gene implicated in aplastic anemia; essential thrombocythemia; and thrombocytosis. Orthologous to human THPO (thrombopoietin).

大鼠 Rat LOC103690065 分子靶点信息

  • 分子名：LOC103690065, thrombopoietin
  • 别称：
    • 无
  • 基因序列：NCBI_Gene: 103690065
  • 蛋白序列：
    • 无

大鼠 Rat Tpo 靶点分子功能（预测）

Human ortholog(s) of this gene implicated in aplastic anemia; essential thrombocythemia; and thrombocytosis. Orthologous to human THPO (thrombopoietin).

THPO 分子产品列表

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