THBS1 靶点信息

THBS1 分子靶点信息概述

  • 分子名：THBS1, thrombospondin 1
  • 别名：TSP1; THBS; TSP; THBS-1; TSP-1
  • 全称：thrombospondin-1p180

THBS1 分子靶点综述

血小板反应素-1(THBS-1)是血小板反应素家族成员，介导细胞-细胞和细胞-基质相互作用。该蛋白可与纤维蛋白原、纤维连接蛋白、层粘连蛋白、V型胶原和整合素α-V/β-1结合。它对血小板聚集、血管生成和肿瘤发生发挥作用。在正常组织中，它是新血管形成和肿瘤发生的天然抑制剂。THBS-1还可正向和负向调控内皮细胞黏附、运动和生长。通过阻断THBS-1与细胞表面受体(CD47)结合，正常组织几乎对肿瘤辐射治疗产生免疫，并有助肿瘤死亡。

THBS1, thrombospondin 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human THBS1 分子靶点信息

  • 分子名：THBS1, thrombospondin 1
  • 别称：
    • glycoprotein G
    • THBS
    • THBS-1
    • thrombospondin-1
    • thrombospondin-1p180
    • thrombospondin-p50
    • TSP
    • TSP-1
    • TSP1
  • 基因序列：NCBI_Gene: 7057
  • 蛋白序列：UniProtKB: P07996

人 Human THBS1靶点分子功能（预测）

Enables several functions, including collagen V binding activity; fibrinogen binding activity; and fibroblast growth factor binding activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and regulation of signal transduction. Acts upstream of or within several processes, including negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell proliferation; and negative regulation of nitric oxide mediated signal transduction. Located in several cellular components, including external side of plasma membrane; extracellular space; and platelet alpha granule. Part of fibrinogen complex. Colocalizes with collagen-containing extracellular matrix. Implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Biomarker of COVID-19; cholangiocarcinoma; obesity; pancreatic cancer (multiple); and urinary bladder cancer.

小鼠 Mouse Thbs1 分子靶点信息

小鼠 Mouse Thbs1 靶点分子功能（预测）

Enables extracellular matrix binding activity. Involved in several processes, including behavioral response to pain; positive regulation of macrophage chemotaxis; and positive regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including cellular response to nitric oxide; circulatory system development; and monocyte aggregation. Located in extracellular space and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Sjogren's syndrome. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1).

大鼠 Rat Thbs1 分子靶点信息

大鼠 Rat Thbs1 靶点分子功能（预测）

Enables transforming growth factor beta binding activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of transforming growth factor beta production; and response to testosterone. Located in cytoplasm and extracellular space. Biomarker of diabetic retinopathy; heart disease; myocardial infarction; and prostate cancer. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1).

THBS1 分子产品列表

THBS1 分子靶点最新资讯