TFRC 靶点信息

TFRC 分子靶点信息概述

  • 分子名：TFRC, transferrin receptor
  • 基因家族：CD molecules; M28 metallopeptidases
  • 别名：CD71; TFR1; p90
  • 全称：transferrin receptor (p90, CD71)

TFRC 分子靶点综述

转铁蛋白受体 CD71 是一种 1180 kDa 的 II 型跨膜蛋白，在细胞表面以同源二聚体的形式存在，对细胞生长至关重要。CD71 表达于未成熟的增殖中的细胞，在静息的成熟淋巴细胞中表达水平较低。抗原或丝裂原刺激的 T 细胞和 B 细胞可上调 CD71 的表达。

TFRC, transferrin receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human TFRC 分子靶点信息

  • 分子名：TFRC, transferrin receptor
  • 别称：
    • CD71
    • IMD46
    • p90
    • T9
    • TFR
    • TFR1
    • TR
    • transferrin receptor (p90, CD71)
    • transferrin receptor protein 1
    • TRFR
  • 基因序列：NCBI_Gene: 7037
  • 蛋白序列：UniProtKB: P02786

人 Human TFRC靶点分子功能（预测）

Enables several functions, including double-stranded RNA binding activity; protein homodimerization activity; and transferrin receptor activity. Involved in several processes, including negative regulation of mitochondrial fusion; positive regulation of NF-kappaB transcription factor activity; and positive regulation of lymphocyte activation. Acts upstream of or within cellular response to xenobiotic stimulus. Located in several cellular components, including basolateral plasma membrane; clathrin-coated pit; and endosome. Is integral component of plasma membrane. Part of HFE-transferrin receptor complex. Implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Biomarker of breast cancer; carcinoma (multiple); iron deficiency anemia; and prostate cancer.

小鼠 Mouse Tfrc 分子靶点信息

小鼠 Mouse Tfrc 靶点分子功能（预测）

Predicted to enable several functions, including Hsp70 protein binding activity; chaperone binding activity; and protein homodimerization activity. Involved in osteoclast differentiation; positive regulation of bone resorption; and positive regulation of lymphocyte proliferation. Acts upstream of or within cellular iron ion homeostasis and cellular response to leukemia inhibitory factor. Located in several cellular components, including clathrin-coated pit; endosome; and extracellular exosome. Part of HFE-transferrin receptor complex. Is expressed in several structures, including alimentary system; extraembryonic component; liver; lung; and meninges. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).

大鼠 Rat Tfrc 分子靶点信息

大鼠 Rat Tfrc 靶点分子功能（预测）

Enables Hsp70 protein binding activity; chaperone binding activity; and transferrin receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Located in several cellular components, including cell surface; extracellular exosome; and recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; muscular atrophy; non-alcoholic fatty liver disease; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).

TFRC 分子产品列表

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