SOS1 靶点信息

SOS1 分子靶点信息概述

  • 分子名：SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
  • 基因家族：Pleckstrin homology domain containing; Dbl family Rho GEFs
  • 别名：HGF; GF1
  • 曾用名：GINGF
  • 全称：gingival fibromatosis, hereditary, 1; son of sevenless homolog 1 (Drosophila)

SOS1 分子靶点综述

肝细胞生长因子（HGF），也称为分散因子，肝细胞生成素A和乳腺生长因子，是一种多效糖蛋白，可调节多种细胞类型的生长和迁移。HGF以全长无活性多肽的形式分泌，然后被丝氨酸蛋白酶切割成60 kDa N端α链和30 kDa C端β链的活性异二聚体分子。HGF由成纤维细胞，脂肪细胞，平滑肌细胞和内皮细胞表达。HGF的血清水平在多种病理中均升高，包括肝损伤，急性肾衰竭，心肌梗塞，1型糖尿病，肥胖症和癌症，以及类风湿关节炎患者的关节液中。

SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SOS1 分子靶点信息

  • 分子名：SOS1, SOS Ras/Rac guanine nucleotide exchange factor 1
  • 别称：
    • GF1
    • GGF1
    • GINGF
    • gingival fibromatosis, hereditary, 1
    • guanine nucleotide exchange factor
    • HGF
    • NS4
    • son of sevenless homolog 1
    • SOS-1
  • 基因序列：NCBI_Gene: 6654
  • 蛋白序列：UniProtKB: Q07889

人 Human SOS1靶点分子功能（预测）

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in axon guidance; cell surface receptor signaling pathway; and leukocyte migration. Predicted to act upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in cytoplasm. Implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Biomarker of cervical cancer and prostate cancer.

小鼠 Mouse Sos1 分子靶点信息

小鼠 Mouse Sos1 靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in several processes, including induction of bacterial agglutination; negative regulation of interleukin-2 production; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in lung; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).

大鼠 Rat Sos1 分子靶点信息

大鼠 Rat Sos1 靶点分子功能（预测）

Enables SH3 domain binding activity. Involved in Ras protein signal transduction; neurotrophin TRK receptor signaling pathway; and positive regulation of signal transduction. Located in neuronal cell body; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1).

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