SERPINC1 靶点信息

SERPINC1 分子靶点信息概述

  • 分子名：SERPINC1, serpin family C member 1
  • 基因家族：Serpin peptidase inhibitors
  • 别名：ATIII; MGC22579
  • 曾用名：AT3
  • 全称：antithrombin III; signal peptide antithrombin part 1; coding sequence signal peptide antithrombin part 1; antithrombin (aa 375-432); serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1

SERPINC1 分子靶点综述

Antithrombin-III，是丝氨酸蛋白酶抑制剂 Serpin 超家族的成员，由 SerpinC1 基因所编码，研 究已发现 Antithrombin-III 是弥散性血管内凝血(DIC)的标志物。该蛋白可以抑制凝血酶和其他活化 丝氨酸蛋白酶凝血系统，调节凝血级联反应。Antithrombin-III 是最重要的凝血因子抑制剂，即使 Antithrombin-III 出现微小的变化，其也能 显著增加血栓栓塞的风险。Antithrombin-III 可以通过依赖性凝血效应或非依赖性凝血效应来抑制 炎症。此外，除了 Antithrombin-III 缺乏症外，Antithrombin-III 及其编码基因 SerpinC1 也可能与许多疾病(如高血压、肾脏疾病)相关。

SERPINC1, serpin family C member 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human SERPINC1 分子靶点信息

  • 分子名：SERPINC1, serpin family C member 1
  • 别称：
    • antithrombin III
    • antithrombin III isoform
    • antithrombin-III
    • AT3
    • AT3D
    • ATIII
    • ATIII-R2
    • ATIII-T1
    • ATIII-T2
    • MGC22579
    • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
    • serine-cysteine proteinase inhibitor clade C member 1
    • serpin C1
    • serpin peptidase inhibitor clade C member 1
    • serpin peptidase inhibitor, clade C (antithrombin), member 1
    • THPH7
  • 基因序列：NCBI_Gene: 462
  • 蛋白序列：UniProtKB: P01008

人 Human SERPINC1靶点分子功能（预测）

Enables identical protein binding activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Biomarker of acute kidney failure; nephrotic syndrome; osteonecrosis; and type 2 diabetes mellitus.

小鼠 Mouse Serpinc1 分子靶点信息

小鼠 Mouse Serpinc1 靶点分子功能（预测）

Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity and response to nutrient. Predicted to act upstream of or within blood coagulation and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in embryo; liver; neural tube; and notochord. Used to study antithrombin III deficiency. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).

大鼠 Rat Serpinc1 分子靶点信息

  • 分子名：Serpinc1, serpin family C member 1
  • 别称：
    • antithrombin III
    • antithrombin-III
    • LOC304917
    • serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1
    • serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
    • serpin peptidase inhibitor, clade C (antithrombin), member 1
  • 基因序列：NCBI_Gene: 304917
  • 蛋白序列：

大鼠 Rat Serpinc1 靶点分子功能（预测）

Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Located in extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1).

SERPINC1 分子产品列表

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