PTX3 靶点信息

PTX3 分子靶点信息概述

  • 分子名：PTX3, pentraxin 3
  • 基因家族：Long pentraxins
  • 别名：TSG-14
  • 曾用名：TNFAIP5
  • 全称：long pentraxin 3; pentaxin-related gene, rapidly induced by IL-1 beta; tumor necrosis factor, alpha-induced protein 5; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin 3, long

PTX3 分子靶点综述

穿透素3(Pentraxin3)也称为肿瘤坏死因子诱导基因14(TSG-14)，是穿透素超家族成员，具有环状多聚体结构。多种类型的细胞，尤其是单核吞噬细胞、树突细胞、成纤维细胞和内皮细胞，对初次炎症信号(如toll样受体、TNF-α、IL-1β)产生应答后，可快速产生并释放Pentraxin3。Pentraxin3是急性期应答蛋白，其在正常情况下含量较低(在小鼠中约25ng/ml，在人类中小于2ng/ml)，而在内毒素性休克、败血症和其它炎症和感染条件下，急剧升高(诱导后6-8小时达到峰值)，含量可达200-800ng/ml，与疾病的严重程度相关。在这些情况下，Pentraxin3是先天免疫和炎症反应局部活化的快速判断标志。研究显示Pentraxin3具有双重作用：保护机体抵抗病原体和调控自身免疫。

PTX3, pentraxin 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PTX3 分子靶点信息

  • 分子名：PTX3, pentraxin 3
  • 别称：
    • long pentraxin 3
    • pentaxin-related gene, rapidly induced by il-1 beta
    • pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5
    • pentaxin-related protein PTX3
    • pentraxin 3, long
    • pentraxin-3
    • pentraxin-related gene, rapidly induced by IL-1 beta
    • pentraxin-related protein PTX3
    • TNF alpha-induced protein 5
    • TNFAIP5
    • TSG-14
    • tumor necrosis factor alpha-induced protein 5
    • tumor necrosis factor-inducible gene 14 protein
    • tumor necrosis factor-inducible protein TSG-14
    • tumor necrosis factor, alpha-induced protein 5
  • 基因序列：NCBI_Gene: 5806
  • 蛋白序列：UniProtKB: P26022

人 Human PTX3靶点分子功能（预测）

Enables complement component C1q complex binding activity; identical protein binding activity; and virion binding activity. Involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Located in extracellular space. Implicated in cystic fibrosis and invasive aspergillosis. Biomarker of hepatitis C; invasive aspergillosis; pelvic inflammatory disease; pulmonary aspergilloma; and toxic shock syndrome.

小鼠 Mouse Ptx3 分子靶点信息

  • 分子名：Ptx3, pentraxin related gene
  • 别称：
    • AI607804
    • expressed sequence AI607804
    • pentraxin 3
    • TSG-14
  • 基因序列：NCBI_Gene: 19288
  • 蛋白序列：

小鼠 Mouse Ptx3 靶点分子功能（预测）

Enables (1->3)-beta-D-glucan binding activity. Acts upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Located in extracellular matrix. Is expressed in cochlea; cochlea epithelium; inner ear vestibular component; organ of Corti; and stria vascularis. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3).

大鼠 Rat Ptx3 分子靶点信息

  • 分子名：Ptx3, pentraxin 3
  • 别称：
    • LOC689388
    • pentraxin 3, long
    • pentraxin related
    • pentraxin related gene
    • pentraxin-related protein PTX3
    • similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)
  • 基因序列：NCBI_Gene: 689388
  • 蛋白序列：UniProtKB: D3ZT94

大鼠 Rat Ptx3 靶点分子功能（预测）

Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; complement component C1q complex binding activity; and virion binding activity. Predicted to be involved in innate immune response; modulation by host of viral process; and negative regulation of viral entry into host cell. Predicted to act upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3).

PTX3 分子产品列表

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