PRLR 靶点信息

PRLR 分子靶点信息概述

  • 分子名：PRLR, prolactin receptor

PRLR 分子靶点综述

催乳素受体(PRLR)是细胞因子受体，由位于染色体5p13-14上的基因编码，可作为跨膜受体与催乳素相互作用。PRLR包括一个可结合催乳素的胞外区、一个跨膜区和一个胞质区。PRLR广泛在乳腺、胎盘、肾脏、肝脏和胰腺中表达，除了催乳素外，它还可被生长激素(GH)和人胎盘泌乳素(hPL)活化。研究表明PRLR的异常与某些肿瘤尤其是乳腺癌的发病及预后等密切关联。与PRLR特异性结合可刺激乳腺癌细胞生长，一些可与PRLR结合、但不使之形成二聚体的拮抗剂可抑制乳腺癌细胞生长。PRLR还存在几种异构体，其中可溶性的PRLR不能转导催乳素信号。

PRLR, prolactin receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PRLR 分子靶点信息

  • 分子名：PRLR, prolactin receptor
  • 别称：
    • delta 4-delta 7/11 truncated prolactin receptor
    • delta 4-SF1b truncated prolactin receptor
    • HPRL
    • hPRL receptor
    • hPRLrI
    • MFAB
    • PRL-R
    • prolactin receptor delta 7/11
    • RI-PRLR
    • secreted prolactin binding protein
  • 基因序列：NCBI_Gene: 5618
  • 蛋白序列：UniProtKB: P16471

人 Human PRLR靶点分子功能（预测）

Enables peptide hormone binding activity and prolactin receptor activity. Involved in activation of Janus kinase activity; activation of transmembrane receptor protein tyrosine kinase activity; and negative regulation of apoptotic process. Located in cell surface. Implicated in hyperprolactinemia.

小鼠 Mouse Prlr 分子靶点信息

小鼠 Mouse Prlr 靶点分子功能（预测）

Enables prolactin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor).

大鼠 Rat Prlr 分子靶点信息

大鼠 Rat Prlr 靶点分子功能（预测）

Enables prolactin receptor activity and protein kinase binding activity. Predicted to be involved in several processes, including activation of protein kinase activity; cytokine-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor).

PRLR 分子产品列表

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