PRL 靶点信息

PRL 分子靶点信息概述

  • 分子名：PRL, prolactin
  • 基因家族：Growth hormone family; Neuropeptides

PRL 分子靶点综述

催乳素(PRL)是一种由 PRL 基因编码的神经内分泌垂体激素，由垂体、胎盘、脑、子宫、真皮成纤维细胞、蜕膜、B 细胞、T 细胞、自然杀伤细胞和乳腺癌细胞合成。催乳素在人类妊娠早期表达较低，被胎盘催乳素取代，但在妊娠晚期 表达增加。催乳素在新陈代谢、免疫系统调节和胰腺发育中起到重要作用。催乳素也以细胞因子样方式起作用，是免疫 系统的重要调节因子。作为生长、分化和抗凋亡因子，其具有重要的细胞周期相关功能。作为一种与细胞因子样受体结 合的生长因子，它可以通过多种途径影响造血、血管生成，并参与血液凝固的调节。

PRL, prolactin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PRL 分子靶点信息

人 Human PRL靶点分子功能（预测）

Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including negative regulation of endothelial cell proliferation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in secretory granule. Predicted to be active in extracellular space. Implicated in carotid artery disease. Biomarker of hepatocellular carcinoma; hypoglycemia; obesity; and severe acute respiratory syndrome.

小鼠 Mouse Prl 分子靶点信息

小鼠 Mouse Prl 靶点分子功能（预测）

Predicted to enable hormone activity and prolactin receptor binding activity. Acts upstream of or within several processes, including mammary gland development; maternal behavior; and positive regulation of receptor signaling pathway via JAK-STAT. Located in secretory granule. Is expressed in hippocampus; pituitary gland; placenta; and trophoblast giant cell. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin).

大鼠 Rat Prl 分子靶点信息

大鼠 Rat Prl 靶点分子功能（预测）

Predicted to enable hormone activity and prolactin receptor binding activity. Involved in several processes, including parturition; response to estradiol; and response to lipopolysaccharide. Located in extracellular region and secretory granule. Used to study portal hypertension and prolactinoma. Biomarker of hyperprolactinemia; prolactinoma; and renovascular hypertension. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin).

PRL 分子产品列表

PRL 分子靶点最新资讯