PLAUR 靶点信息

PLAUR 分子靶点信息概述

  • 分子名：PLAUR, plasminogen activator, urokinase receptor
  • 基因家族：CD molecules; LY6/PLAUR domain containing
  • 别名：URKR; UPAR; CD87
  • 全称：urokinase-type plasminogen activator (uPA) receptor; urokinase plasminogen activator surface receptor

PLAUR 分子靶点综述

尿激酶型纤溶酶原激活物受体(uPAR)是一个细胞表面受体，高亲和力结合尿激酶型纤溶酶原激活物(uPA)，从而促进纤溶酶原细胞的激活。它是一个通过GPI锚定在细胞膜上的多域糖蛋白，最初被鉴定为细胞表面尿激酶饱和结合位点。uPAR结合尿激酶，限制最靠近细胞膜周边的血纤维蛋白溶酶原的活化。除了主要配体尿激酶外，uPAR还与其它蛋白有相互作用，其中玻连蛋白是uPAR相关蛋白和整合素家族膜蛋白。uPAR是纤溶酶原激活系统的一部分，在健康的机体中，参与组织重组如乳腺退化和伤口愈合。uPAR参与其它癌症相关过程，如细胞迁移、细胞周期调控、细胞黏附。

PLAUR, plasminogen activator, urokinase receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PLAUR 分子靶点信息

  • 分子名：PLAUR, plasminogen activator, urokinase receptor
  • 别称：
    • CD87
    • monocyte activation antigen Mo3
    • U-PAR
    • u-plasminogen activator receptor form 2
    • UPAR
    • URKR
    • urokinase plasminogen activator surface receptor
    • urokinase-type plasminogen activator (uPA) receptor
  • 基因序列：NCBI_Gene: 5329
  • 蛋白序列：UniProtKB: Q03405

人 Human PLAUR靶点分子功能（预测）

Enables enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of release of cytochrome c from mitochondria. Located in cell surface and plasma membrane. Implicated in rheumatoid arthritis. Biomarker of several diseases, including Lyme disease; cardiovascular system disease (multiple); end stage renal disease; hepatitis B; and melioidosis.

小鼠 Mouse Plaur 分子靶点信息

小鼠 Mouse Plaur 靶点分子功能（预测）

Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of apoptotic signaling pathway; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of release of cytochrome c from mitochondria. Is integral component of plasma membrane. Is expressed in several structures, including decidua; early conceptus; and spleen. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor).

大鼠 Rat Plaur 分子靶点信息

  • 分子名：Plaur, plasminogen activator, urokinase receptor
  • 别称：
    • Par
    • plasminogen activator urokinase receptor 3
    • plasminogen activator, urokinase receptor 3
    • Plaur3
    • U-PAR
    • uPAR
    • uPAR-2
    • uPAR-3
    • urinary plasminogen activator receptor 2
    • urinary plasminogen activator receptor 3
    • urokinase plasminogen activator receptor
    • urokinase plasminogen activator surface receptor
  • 基因序列：NCBI_Gene: 50692
  • 蛋白序列：

大鼠 Rat Plaur 靶点分子功能（预测）

Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including epithelial cell differentiation involved in prostate gland development; skeletal muscle tissue regeneration; and spermatogenesis. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Biomarker of chronic obstructive pulmonary disease; myocardial infarction; and status epilepticus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor).

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