文章目录[隐藏]
- PLAT, tPA 分子靶点信息概述
- PLAT, tPA 分子靶点综述
- PLAT, tPA 分子靶点种属信息
- PLAT, tPA 分子产品列表
- Human t-Plasminogen Activator (tPA) ELISA Kit检测试剂盒(酶联免疫吸附法)
- Human t-Plasminogen Activator/tPA Standard (人组织型纤溶酶原激活剂 标准品)
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PLAT, tPA 分子靶点信息概述
- 分子名:PLAT, plasminogen activator, tissue type
- 曾用名:plasminogen activator, tissue
PLAT, tPA 分子靶点综述
组织型纤溶酶原激活剂(tPA)是一种丝氨酸蛋白酶,它将纤溶酶原转化为活性丝氨酸蛋白酶纤溶酶,丝氨酸蛋白酶纤溶酶是去除纤维蛋白沉积的主要酶。tPA 的生物学效应包括血块降解、血管重塑、突触可塑性和创伤后大脑的神经变性。通过低密度脂蛋白受体相关蛋白-1 介导的内吞作用,tPA 也能够迅速从细胞外和血管内清除。tPA 的表达或活性增加与过度出血有关,而 tPA 活性降低与血栓形成和栓塞形成有关。在大脑中,tPA 在神经元、星形细胞、小胶质细胞和血管实质内皮细胞中表达。在中风、缺氧、兴奋性毒性创伤和应激诱导的认知功能下降后,大脑中 tPA 的表达发生了变化。
PLAT, tPA 分子靶点种属信息
人 Human PLAT, tPA 分子靶点信息
- 分子名:PLAT, plasminogen activator, tissue type
- 别称:
- alteplase
- DKFZp686I03148
- plasminogen/activator kringle
- reteplase
- T-PA
- t-plasminogen activator
- tissue plasminogen activator (t-PA)
- tissue-type plasminogen activator
- TPA
- 基因序列:NCBI_Gene: 5327
- 蛋白序列:UniProtKB: P00750
人 Human PLAT, tPA 靶点分子功能(预测)
Enables phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in negative regulation of proteolysis and plasminogen activation. Located in cell surface; cytoplasm; and serine protease inhibitor complex. Implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Biomarker of several diseases, including Henoch-Schoenlein purpura; autoimmune thrombocytopenic purpura; blood coagulation disease (multiple); diabetes mellitus (multiple); and hemolytic-uremic syndrome.
小鼠 Mouse Plat 分子靶点信息
- 分子名:Plat, plasminogen activator, tissue
- 别称:
- AU020998
- AW212668
- D8Ertd2e
- DNA segment, Chr 8, ERATO Doi 2, expressed
- expressed sequence AU020998
- expressed sequence AW212668
- MGC:18508
- t-PA
- tPA
- 基因序列:NCBI_Gene: 18791
- 蛋白序列:
小鼠 Mouse Plat 靶点分子功能(预测)
Enables serine-type endopeptidase activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; response to hypoxia; and smooth muscle cell migration. Located in several cellular components, including apical part of cell; extracellular space; and secretory granule. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Orthologous to human PLAT (plasminogen activator, tissue type).
大鼠 Rat Plat 分子靶点信息
- 分子名:Plat, plasminogen activator, tissue
- 别称:
- LOC100910418
- PATISS
- plasminogen activator, tissue
- t-PA
- t-plasminogen activator
- tissue plasminogen activator
- tissue-type plasminogen activator
- tissue-type plasminogen activator-like
- tPA
- 基因序列:NCBI_Gene: 25692
- 蛋白序列:
大鼠 Rat Plat 靶点分子功能(预测)
Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; plasminogen activation; and prevention of polyspermy. Located in extracellular space. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Orthologous to human PLAT (plasminogen activator, tissue type).
PLAT, tPA 分子产品列表
-
- EK1307
- ELISA试剂盒
Human t-Plasminogen Activator (tPA) ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥2,000.00 – ¥3,400.00