PLAT 靶点信息

PLAT, tPA 分子靶点信息概述

  • 分子名：PLAT, plasminogen activator, tissue type
  • 曾用名：plasminogen activator, tissue

PLAT, tPA 分子靶点综述

组织型纤溶酶原激活剂(tPA)是一种丝氨酸蛋白酶，它将纤溶酶原转化为活性丝氨酸蛋白酶纤溶酶，丝氨酸蛋白酶纤溶酶是去除纤维蛋白沉积的主要酶。tPA 的生物学效应包括血块降解、血管重塑、突触可塑性和创伤后大脑的神经变性。通过低密度脂蛋白受体相关蛋白-1 介导的内吞作用，tPA 也能够迅速从细胞外和血管内清除。tPA 的表达或活性增加与过度出血有关，而 tPA 活性降低与血栓形成和栓塞形成有关。在大脑中，tPA 在神经元、星形细胞、小胶质细胞和血管实质内皮细胞中表达。在中风、缺氧、兴奋性毒性创伤和应激诱导的认知功能下降后，大脑中 tPA 的表达发生了变化。

PLAT, tPA 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PLAT, tPA 分子靶点信息

  • 分子名：PLAT, plasminogen activator, tissue type
  • 别称：
    • alteplase
    • DKFZp686I03148
    • plasminogen/activator kringle
    • reteplase
    • T-PA
    • t-plasminogen activator
    • tissue plasminogen activator (t-PA)
    • tissue-type plasminogen activator
    • TPA
  • 基因序列：NCBI_Gene: 5327
  • 蛋白序列：UniProtKB: P00750

人 Human PLAT, tPA 靶点分子功能（预测）

Enables phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in negative regulation of proteolysis and plasminogen activation. Located in cell surface; cytoplasm; and serine protease inhibitor complex. Implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Biomarker of several diseases, including Henoch-Schoenlein purpura; autoimmune thrombocytopenic purpura; blood coagulation disease (multiple); diabetes mellitus (multiple); and hemolytic-uremic syndrome.

小鼠 Mouse Plat 分子靶点信息

  • 分子名：Plat, plasminogen activator, tissue
  • 别称：
    • AU020998
    • AW212668
    • D8Ertd2e
    • DNA segment, Chr 8, ERATO Doi 2, expressed
    • expressed sequence AU020998
    • expressed sequence AW212668
    • MGC:18508
    • t-PA
    • tPA
  • 基因序列：NCBI_Gene: 18791
  • 蛋白序列：

小鼠 Mouse Plat 靶点分子功能（预测）

Enables serine-type endopeptidase activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; response to hypoxia; and smooth muscle cell migration. Located in several cellular components, including apical part of cell; extracellular space; and secretory granule. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Orthologous to human PLAT (plasminogen activator, tissue type).

大鼠 Rat Plat 分子靶点信息

  • 分子名：Plat, plasminogen activator, tissue
  • 别称：
    • LOC100910418
    • PATISS
    • plasminogen activator, tissue
    • t-PA
    • t-plasminogen activator
    • tissue plasminogen activator
    • tissue-type plasminogen activator
    • tissue-type plasminogen activator-like
    • tPA
  • 基因序列：NCBI_Gene: 25692
  • 蛋白序列：

大鼠 Rat Plat 靶点分子功能（预测）

Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; plasminogen activation; and prevention of polyspermy. Located in extracellular space. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia due to decreased release of PLAT. Orthologous to human PLAT (plasminogen activator, tissue type).

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