PCSK9 靶点信息

PCSK9 分子靶点信息概述

  • 分子名：PCSK9, proprotein convertase subtilisin/kexin type 9
  • 基因家族：Proprotein convertase subtilisin/kexin family
  • 别名：NARC-1; FH3
  • 曾用名：HCHOLA3
  • 全称：hypercholesterolemia, autosomal dominant 3

PCSK9 分子靶点综述

前蛋白转化酶枯草溶菌素(PCSK9)是分泌型枯草杆菌蛋白酶家族的蛋白酶K亚家族成员。它在内质网中进行分子内自催化加工，以可溶性酶原形式被合成。PCSK9与低密度脂蛋白(LDL)胆固醇受体结合，诱导LDLR降解。PCSK9变异可降低或升高循环的胆固醇。其它的变异与非常罕见的常染色体显性遗传的家族性高胆固醇血症(HCHOLA3)有关。突变增强了其蛋白酶活性，降低LDLR水平，阻止细胞吸收胆固醇。

PCSK9, proprotein convertase subtilisin/kexin type 9 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human PCSK9 分子靶点信息

  • 分子名：PCSK9, proprotein convertase subtilisin/kexin type 9
  • 别称：
    • convertase subtilisin/kexin type 9 preproprotein
    • FH3
    • FHCL3
    • HCHOLA3
    • LDLCQ1
    • NARC-1
    • NARC1
    • neural apoptosis regulated convertase 1
    • neural apoptosis-regulated convertase 1
    • PC9
    • proprotein convertase 9
    • subtilisin/kexin-like protease PC9
  • 基因序列：NCBI_Gene: 255738
  • 蛋白序列：UniProtKB: Q8NBP7

人 Human PCSK9靶点分子功能（预测）

Enables several functions, including lipoprotein particle receptor binding activity; serine-type endopeptidase activity; and sodium channel inhibitor activity. Involved in several processes, including cholesterol homeostasis; low-density lipoprotein particle receptor catabolic process; and regulation of receptor-mediated endocytosis. Located in several cellular components, including Golgi apparatus; endosome; and perinuclear region of cytoplasm. Part of PCSK9-AnxA2 complex and PCSK9-LDLR complex. Implicated in familial hypercholesterolemia and hypobetalipoproteinemia.

小鼠 Mouse Pcsk9 分子靶点信息

  • 分子名：Pcsk9, proprotein convertase subtilisin/kexin type 9
  • 别称：
    • AI415265
    • AI747682
    • expressed sequence AI415265
    • expressed sequence AI747682
    • Narc1
  • 基因序列：NCBI_Gene: 100102
  • 蛋白序列：

小鼠 Mouse Pcsk9 靶点分子功能（预测）

Enables apolipoprotein binding activity; lipoprotein particle binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to starvation; and regulation of neuron apoptotic process. Acts upstream of or within several processes, including low-density lipoprotein receptor particle metabolic process; regulation of low-density lipoprotein particle receptor catabolic process; and triglyceride metabolic process. Located in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and extracellular space. Is expressed in several structures, including alimentary system; cerebellum; genitourinary system; liver; and telencephalon. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9).

大鼠 Rat Pcsk9 分子靶点信息

  • 分子名：Pcsk9, proprotein convertase subtilisin/kexin type 9
  • 别称：
    • NARC-1
    • Narc1
    • neural apoptosis regulated convertase 1
    • neural apoptosis-regulated convertase 1
    • PC9
    • proprotein convertase 9
    • proprotein convertase PC9
    • subtilisin/kexin-like protease PC9
  • 基因序列：NCBI_Gene: 298296
  • 蛋白序列：UniProtKB: P59996

大鼠 Rat Pcsk9 靶点分子功能（预测）

Predicted to enable several functions, including lipoprotein particle binding activity; lipoprotein particle receptor binding activity; and serine-type endopeptidase activity. Involved in several processes, including cellular response to insulin stimulus; cholesterol homeostasis; and protein autoprocessing. Located in extracellular space and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in familial hypercholesterolemia and hypobetalipoproteinemia. Orthologous to human PCSK9 (proprotein convertase subtilisin/kexin type 9).

PCSK9 分子产品列表

PCSK9 分子靶点最新资讯

ELISA系列（5）冠心病相关热门因子介绍