OSMR 靶点信息

OSMR 分子靶点信息概述

  • 分子名：OSMR, oncostatin M receptor
  • 基因家族：Fibronectin type III domain containing
  • 别名：OSMRB; OSMRbeta
  • 全称：Oncostatin-M-specific receptor subunit beta

OSMR 分子靶点综述

抑瘤素M受体（Onconstatin M receptor, OSMR）是白细胞介素-6受体家族成员之一，该家族执行多种细胞功能，在炎症反应，代谢性疾病及细胞生长分化等生物学过程中起着重要作用。OSMR与gp130结合形成对OSM具有高亲和度的受体。在胃癌、结直肠癌、乳腺癌及胶质瘤等癌症样本中均可检测到OSM及OSMR的过度表达，因此靶向 OSMR 是一种治疗各种癌症以及皮肤疾病的重要治疗手段。

OSMR, oncostatin M receptor 分子靶点种属信息


人 Human小鼠 Mouse大鼠 Rat

人 Human OSMR 分子靶点信息

  • 分子名：OSMR, oncostatin M receptor
  • 别称：
    • IL-31 receptor subunit beta
    • IL-31R subunit beta
    • IL-31R-beta
    • IL-31RB
    • interleukin-31 receptor subunit beta
    • MGC150626
    • MGC150627
    • MGC75127
    • oncostatin-M specific receptor beta subunit
    • oncostatin-M-specific receptor subunit beta
    • OSMRB
    • OSMRbeta
    • PLCA1
  • 基因序列：NCBI_Gene: 9180
  • 蛋白序列：UniProtKB: Q99650

人 Human OSMR靶点分子功能（预测）

Enables growth factor binding activity. Contributes to oncostatin-M receptor activity. Involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Part of apical plasma membrane and oncostatin-M receptor complex. Implicated in primary localized cutaneous amyloidosis 1.

小鼠 Mouse Omsr 分子靶点信息

小鼠 Mouse Osmr 靶点分子功能（预测）

Enables cytokine binding activity and oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to act upstream of or within cell surface receptor signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; hemolymphoid system; lung; sensory organ; and skeletal system. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor).

大鼠 Rat Osmr 分子靶点信息

  • 分子名：Osmr, oncostatin M receptor
  • 别称：
    • IL-31 receptor subunit beta
    • IL-31R subunit beta
    • IL-31R-beta
    • IL-31RB
    • interleukin-31 receptor subunit beta
    • oncostatin M specific receptor
    • oncostatin-M specific receptor subunit beta
    • oncostatin-M-specific receptor subunit beta
  • 基因序列：NCBI_Gene: 310132
  • 蛋白序列：

大鼠 Rat Osmr 靶点分子功能（预测）

Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; cytokine receptor activity; and growth factor binding activity. Predicted to contribute to oncostatin-M receptor activity. Predicted to be involved in oncostatin-M-mediated signaling pathway and positive regulation of cell population proliferation. Predicted to be located in apical plasma membrane. Predicted to be part of oncostatin-M receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 1. Orthologous to human OSMR (oncostatin M receptor).

OSMR 分子产品列表


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