NPPC 靶点信息

NPPC 分子靶点信息概述

  • 分子名：NPPC, natriuretic peptide C
  • 基因家族：Neuropeptides
  • 别名：CNP
  • 全称：natriuretic peptide precursor C

NPPC 分子靶点综述

C肽(C-Peptide)又称连接肽，由胰岛β细胞分泌，与胰岛素有一个共同的前体胰岛素原。它是一种由31个氨基酸组成的多肽，在胰岛素原分子中将胰岛素的A链和B链连接起来。C肽已被证明以纳米摩尔浓度结合到许多类型细胞(如神经元、内皮细胞、成纤维细胞和肾小管的表面)的G蛋白偶联的受体。C肽通过下调内皮细胞表面粘附分子、减少炎性细胞因子产生和保护血管平滑肌细胞免受有害胰岛素作用，从而发挥血管抗炎作用。在患有C肽缺乏(1型模型)肾病的动物中，给药C肽可改善肾功能和结构，减少尿白蛋白的排泄，也可预防或减少因系膜基质扩张的糖尿病引起的肾小球改变。

NPPC, natriuretic peptide C 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NPPC 分子靶点信息

  • 分子名：NPPC, natriuretic peptide C
  • 别称：
    • C-type natriuretic peptide
    • CNP
    • CNP2
    • natriuretic peptide precursor C
    • natriuretic peptide precursor type C
  • 基因序列：NCBI_Gene: 4880
  • 蛋白序列：UniProtKB: P23582

人 Human NPPC靶点分子功能（预测）

Enables hormone receptor binding activity. Involved in protein folding and receptor guanylyl cyclase signaling pathway. Acts upstream of or within negative regulation of meiotic cell cycle and negative regulation of oocyte maturation. Part of protein-containing complex. Implicated in hypertension. Biomarker of arteriosclerosis; end stage renal disease; hypertension; and toxic shock syndrome.

小鼠 Mouse Nppc 分子靶点信息

小鼠 Mouse Nppc 靶点分子功能（预测）

Enables signaling receptor binding activity. Involved in growth plate cartilage chondrocyte differentiation and growth plate cartilage chondrocyte proliferation. Acts upstream of or within several processes, including negative regulation of meiotic cell cycle; negative regulation of oocyte maturation; and regulation of growth. Predicted to be located in extracellular space and secretory granule. Predicted to be part of protein-containing complex. Is expressed in central nervous system and vertebral cartilage condensation. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C).

大鼠 Rat Nppc 分子靶点信息

  • 分子名：Nppc, natriuretic peptide C
  • 别称：
    • C-type natriuretic peptide
    • natriuretic peptide precursor C
    • natriuretic peptide precursor type C
  • 基因序列：NCBI_Gene: 114593
  • 蛋白序列：UniProtKB: P55207

大鼠 Rat Nppc 靶点分子功能（预测）

Enables hormone activity. Involved in several processes, including negative regulation of biosynthetic process; positive regulation of cGMP-mediated signaling; and positive regulation of osteoblast differentiation. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in extracellular space and secretory granule. Biomarker of aortic valve stenosis and heart disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPPC (natriuretic peptide C).

NPPC 分子产品列表

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