NOTCH1 靶点信息

NOTCH1 分子靶点信息概述

  • 分子名：NOTCH1, notch receptor 1
  • 基因家族：Notch receptors; MicroRNA protein coding host genes
  • 曾用名：TAN1
  • 全称：Notch (Drosophila) homolog 1 (translocation-associated); Notch homolog 1, translocation-associated (Drosophila); notch 1

NOTCH1 分子靶点综述

Notch信号通路是一种普遍存在的控制发育过程的通路。Notch家族由一组高度保守的蛋白质组成，它们既是细胞表面受体，又是基因转录的直接调节者。它在细胞增殖、凋亡、分化以及一系列生理和病理过程中起着重要的调节作用，在癌症的发生、发展中起着至关重要的作用。Notch-1是一种300kDa的1型跨膜糖蛋白，是参与发育过程的四种Notch同源物之一。这种1型跨膜蛋白家族的成员具有相同的结构特征，包括由多个表皮生长因子样（EGF）重复序列组成的胞外结构域和由多个不同结构域类型组成的胞内结构域。Notch家族成员通过控制细胞命运决定，在多种发育过程中发挥作用。Notch-1途径与细胞分化、增殖、凋亡和粘附性相关。Notch-1信号通路的异常激活已被证实与癌症的发生发展有关。

NOTCH1, notch receptor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human NOTCH1 分子靶点信息

  • 分子名：NOTCH1, notch receptor 1
  • 别称：
    • AOS5
    • AOVD1
    • hN1
    • neurogenic locus notch homolog protein 1
    • notch 1
    • notch gene homolog 1, (drosophila)
    • Notch homolog 1, translocation-associated
    • TAN1
    • translocation-associated notch protein TAN-1
  • 基因序列：NCBI_Gene: 4851
  • 蛋白序列：UniProtKB: P46531

人 Human NOTCH1靶点分子功能（预测）

Enables identical protein binding activity. Involved in several processes, including heart development; negative regulation of endothelial cell migration; and positive regulation of intracellular signal transduction. Part of MAML1-RBP-Jkappa- ICN1 complex and receptor complex. Implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Biomarker of cholangiocarcinoma and endometrial cancer.

小鼠 Mouse Notch1 分子靶点信息

小鼠 Mouse Notch1 靶点分子功能（预测）

Enables several functions, including Notch binding activity; chromatin DNA binding activity; and transcription coactivator activity. Involved in several processes, including blood vessel endothelial cell differentiation; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; nervous system development; and tube morphogenesis. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).

大鼠 Rat Notch1 分子靶点信息

  • 分子名：Notch1, notch receptor 1
  • 别称：
    • Drosophila Notch homolog 1
    • Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
    • neurogenic locus notch homolog protein 1
    • NOTCH
    • notch 1
    • Notch gene homolog 1
    • Notch gene homolog 1 (Drosophila)
    • Notch homolog 1, translocation-associated
    • Notch homolog 1, translocation-associated (Drosophila)
    • TAN1
  • 基因序列：NCBI_Gene: 25496
  • 蛋白序列：UniProtKB: Q07008

大鼠 Rat Notch1 靶点分子功能（预测）

Enables transmembrane signaling receptor activity. Involved in several processes, including nervous system development; positive regulation of cell differentiation; and positive regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleus. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).

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