MUC16 靶点信息

MUC16 分子靶点信息概述

  • 分子名：MUC16, mucin 16, cell surface associated
  • 基因家族：Mucins
  • 别名：CA125; FLJ14303; CA-125
  • 全称：cancer antigen 125

MUC16 分子靶点综述

癌抗原125或糖类抗原125(CA125)也称为粘蛋白16或MUC16，是一种在人类中被MUC16基因编码的蛋白质。MUC16是粘蛋白家族糖蛋白的一员。它是眼表、呼吸道和女性生殖道上皮的一个组成部分。由于MUC16高度糖基化，它可在上皮细胞顶端膜上形成亲水性的环境，作为润滑屏障抵御外来颗粒和感染因子。此外，已被证实MUC16的细胞质末端通过结合ERM蛋白家族成员与细胞骨架相互作用。MUC16的表达在干眼症、囊性纤维化和几种癌症中有所改变。

MUC16, mucin 16, cell surface associated 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MUC16 分子靶点信息

  • 分子名：MUC16, mucin 16, cell surface associated
  • 别称：
    • CA-125
    • CA125
    • CA125 ovarian cancer antigen
    • cancer antigen 125
    • FLJ14303
    • MUC-16
    • mucin 16
    • mucin-16
    • mucin-16 long isoform
    • mucin-16 short isoform
    • ovarian cancer-related tumor marker CA125
    • ovarian carcinoma antigen CA125
  • 基因序列：NCBI_Gene: 94025
  • 蛋白序列：UniProtKB: Q8WXI7

人 Human MUC16靶点分子功能（预测）

Predicted to act upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Is extrinsic component of membrane. Implicated in ovarian cancer. Biomarker of Sjogren's syndrome; cholangiocarcinoma; dry eye syndrome; keratoconjunctivitis; and pancreatic cancer.

小鼠 Mouse Muc16 分子靶点信息

小鼠 Mouse Muc16 靶点分子功能（预测）

Acts upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; mesothelium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated).

大鼠 Rat Muc16 分子靶点信息

  • 分子名：Muc16, mucin 16, cell surface associated
  • 别称：
    • LOC315451
    • mucin 16
    • mucin-16
    • RGD1308422
    • similar to ovarian cancer related tumor marker CA125
  • 基因序列：NCBI_Gene: 315451
  • 蛋白序列：暂无

大鼠 Rat Muc16 靶点分子功能（预测）

Predicted to act upstream of or within negative regulation of epithelial cell proliferation; negative regulation of interleukin-6 production; and negative regulation of wound healing. Located in extracellular space. Biomarker of ovarian carcinoma. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human MUC16 (mucin 16, cell surface associated).

MUC16 分子产品列表

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