MST1 靶点信息

MST1 分子靶点信息概述

  • 分子名：MST1, macrophage stimulating 1
  • 别名：MSP; NF15S2
  • 曾用名：D3F15S2; HGFL; DNF15S2
  • 全称：hepatocyte growth factor-like

MST1 分子靶点综述

巨噬细胞刺激蛋白（MSP），也称为肝细胞生长因子样蛋白（HGFL）和MST1，是生长因子HGF家族的成员。 MSP以无活性的单链前体（pro-MSP）的形式分泌，是跨膜受体酪氨酸激酶受体（RON）的配体（RON；也称为MST1R）。自发现以来，已证明MSP在调节多种疾病模型的外周组织中的炎症中起关键作用。最近的证据还表明MSP在调节肝脂质和葡萄糖代谢中具有有益作用，从而暗示MSP作为维持代谢稳态的关键调节剂，同时抑制炎症过程。MSP诱导巨噬细胞和角质形成细胞增殖以及破骨细胞活化。它还通过巨噬细胞抑制LPS或IFN诱导的iNOS和IL-12表达，并可阻止从细胞外基质分离得到的上皮细胞发生凋亡。

MST1, macrophage stimulating 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MST1 分子靶点信息

  • 分子名：MST1, macrophage stimulating 1
  • 别称：
    • D3F15S2
    • DNF15S2
    • hepatocyte growth factor-like protein
    • hepatocyte growth factor-like protein homolog
    • HGFL
    • macrophage stimulating 1 (hepatocyte growth factor-like)
    • macrophage stimulatory protein
    • macrophage-stimulating protein
    • MSP
    • NF15S2
  • 基因序列：NCBI_Gene: 4485
  • 蛋白序列：UniProtKB: P26927

人 Human MST1靶点分子功能（预测）

Enables receptor tyrosine kinase binding activity. Involved in histone H2A-S139 phosphorylation; negative regulation of gluconeogenesis; and regulation of cAMP-dependent protein kinase activity. Located in extracellular space. Part of collagen-containing extracellular matrix.

小鼠 Mouse Mst1 分子靶点信息

小鼠 Mouse Mst1 靶点分子功能（预测）

Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including embryo implantation; mammary duct terminal end bud growth; and positive regulation of mammary gland epithelial cell proliferation. Located in vacuole. Is expressed in esophagus epithelium; liver; liver parenchyma; pharynx epithelium; and stomach proventricular region epithelium. Orthologous to several human genes including MST1 (macrophage stimulating 1).

大鼠 Rat Mst1 分子靶点信息

  • 分子名：Mst1, macrophage stimulating 1
  • 别称：
    • D8h3f15s2
    • E2F transcription factor 2
    • E2F2
    • hepatocyte growth factor-like protein
    • Macrophage stimulating 1 (hepatocyte growth factor-like)
  • 基因序列：NCBI_Gene: 24566
  • 蛋白序列：

大鼠 Rat Mst1 靶点分子功能（预测）

Enables enzyme binding activity. Involved in cellular response to hypoxia; flagellated sperm motility; and spermatogenesis. Located in cytoplasm. Orthologous to several human genes including MST1 (macrophage stimulating 1).

MST1 分子产品列表

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