MS4A1 靶点信息

MS4A1 分子靶点信息概述

  • 分子名：MS4A1, membrane spanning 4-domains A1
  • 基因家族：CD molecules; Membrane spanning 4-domains
  • 别名：B1; Bp35; FMC7
  • 曾用名：CD20
  • 全称：membrane-spanning 4-domains, subfamily A, member 1

MS4A1 分子靶点综述

CD20是一种分子量为33-37 kD的磷酸化蛋白质分子，表达在B淋巴细胞及其前体，但最早期的祖细胞不表达、滤泡树突状细胞及小部分T细胞弱表达。它主要参与调节B淋巴细胞的增殖与分化，在免疫系统起重要作用。由于CD20在恶性B细胞表面的表达特点及与抗体结合不发生内吞作用，已经将其作为免疫治疗霍奇金淋巴瘤的靶点。

MS4A1, membrane spanning 4-domains A1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MS4A1 分子靶点信息

  • 分子名：MS4A1, membrane spanning 4-domains A1
  • 别称：
    • B-lymphocyte antigen CD20
    • B-lymphocyte cell-surface antigen B1
    • B-lymphocyte surface antigen B1
    • B1
    • Bp35
    • CD20
    • CD20 antigen
    • CD20 receptor
    • CVID5
    • FMC7
    • LEU-16
    • leukocyte surface antigen Leu-16
    • membrane-spanning 4-domains subfamily A member 1
    • membrane-spanning 4-domains, subfamily A, member 1
    • MGC3969
    • MS4A2
    • S7
  • 基因序列：NCBI_Gene: 931
  • 蛋白序列：UniProtKB: P11836

人 Human MS4A1靶点分子功能（预测）

Enables identical protein binding activity and immunoglobulin binding activity. Involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and protein tetramerization. Located in cell surface; nucleoplasm; and plasma membrane raft. Implicated in common variable immunodeficiency.

小鼠 Mouse Ms4a1 分子靶点信息

小鼠 Mouse Ms4a1 靶点分子功能（预测）

Predicted to enable epidermal growth factor receptor binding activity; identical protein binding activity; and immunoglobulin binding activity. Involved in calcium ion import into cytosol. Acts upstream of or within response to bacterium. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human MS4A1 (membrane spanning 4-domains A1).

大鼠 Rat Ms4a1 分子靶点信息

  • 分子名：Ms4a1, membrane spanning 4-domains A1
  • 别称：
    • B-lymphocyte antigen CD20
    • LOC309217
    • membrane-spanning 4-domains, subfamily A, member 1
  • 基因序列：NCBI_Gene: 309217
  • 蛋白序列：UniProtKB: D4A4Y3

大鼠 Rat Ms4a1 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and protein tetramerization. Predicted to act upstream of or within response to bacterium. Predicted to be located in external side of plasma membrane; nucleoplasm; and plasma membrane raft. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human MS4A1 (membrane spanning 4-domains A1).

MS4A1 分子产品列表

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