MMP8 靶点信息

MMP8 分子靶点信息概述

  • 分子名：MMP8, matrix metallopeptidase 8
  • 基因家族：M10 matrix metallopeptidases
  • 曾用名：CLG1
  • 全称：matrix metalloproteinase 8 (neutrophil collagenase)

MMP8 分子靶点综述

基质金属蛋白酶 8 (MMP-8)，又名中性粒细胞胶原酶或 PMNL 胶原酶，是一种存在于大多数哺乳动物结缔组织中的 胶原裂解酶。人类中的 MMP-8 蛋白由 MMP8 基因编码。多种物质，如 IL-1、IL-8、TNF-α 和 GM-CSF，可刺激中性粒 细胞释放 MMP-8，后者是启动 ECM 分解的关键酶。活化的 MMP-8 可裂解天然蛋白如纤连蛋白、软骨蛋白聚糖、丝氨酸 蛋白酶抑制蛋白和多肽。MMP-8 通过预防淋巴结转移来影响乳腺癌细胞的转移行为，强调药物开发中抗目标识别的重要性。MMP-8 通过消 除炎症参与创面修复，为治疗创面愈合不良的新策略开发提供一定的可能性。

MMP8, matrix metallopeptidase 8 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MMP8 分子靶点信息

  • 分子名：MMP8, matrix metallopeptidase 8
  • 别称：
    • CLG1
    • collagenase 2
    • HNC
    • matrix metalloproteinase 8 (neutrophil collagenase)
    • matrix metalloproteinase-8
    • MMP-8
    • neutrophil collagenase
    • PMN leukocyte collagenase
    • PMNL collagenase
    • PMNL-CL
  • 基因序列：NCBI_Gene: 4317
  • 蛋白序列：UniProtKB: P22894

人 Human MMP8靶点分子功能（预测）

Enables serine-type endopeptidase activity. Involved in endodermal cell differentiation and proteolysis. Located in extracellular space. Implicated in breast cancer and carotid artery disease. Biomarker of COVID-19; aortic aneurysm (multiple); arthritis (multiple); breast cancer; and female reproductive organ cancer (multiple).

小鼠 Mouse Mmp8 分子靶点信息

小鼠 Mouse Mmp8 靶点分子功能（预测）

Predicted to enable endopeptidase activity and metal ion binding activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of intracellular signal transduction; and regulation of cytokine production. Located in extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hindlimb digit mesenchyme; musculature; and skeleton. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8).

大鼠 Rat Mmp8 分子靶点信息

大鼠 Rat Mmp8 靶点分子功能（预测）

Enables calcium ion binding activity; metallopeptidase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of neuroinflammatory response; positive regulation of nitric oxide biosynthetic process; and positive regulation of tumor necrosis factor production. Located in extracellular space. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in breast cancer and carotid artery disease. Orthologous to human MMP8 (matrix metallopeptidase 8).

MMP8 分子产品列表

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