MMP3 靶点信息

MMP3 分子靶点信息概述

  • 分子名：MMP3, matrix metallopeptidase 3
  • 基因家族：M10 matrix metallopeptidases
  • 曾用名：STMY1; STMY
  • 全称：matrix metalloproteinase 3 (stromelysin 1, progelatinase); stromelysin 1

MMP3 分子靶点综述

基质金属蛋白酶3(MMP-3)，又名基质分解素-1，在人类中由MMP3基因编码。MMP3的表达主要在转录水平上调控，转录水平上的基因启动子对多种刺激物包括生长因子、细胞因子、促癌剂和原癌基因产物作出应答。MMP-3酶降解II、III、IV、IX和X型胶原蛋白、蛋白聚糖、纤维连接蛋白、层粘连蛋白和弹性蛋白。另外，MMP-3还可激活其它MMPs如MMP-1、MMP-7和MMP-9，因此MMP-3在结缔组织重塑中起关键作用。该酶参与伤口修复、动脉粥样硬化进展和肿瘤启动。MMP-3野生型和基因敲除的小鼠研究表明，MMP-3增加了外伤性损伤后的血脑屏障通透性。细胞核MMP-3可作为转录因子和蛋白酶发挥作用。

MMP3, matrix metallopeptidase 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MMP3 分子靶点信息

  • 分子名：MMP3, matrix metallopeptidase 3
  • 别称：
    • CHDS6
    • matrix metallopeptidase 3 (stromelysin 1, progelatinase)
    • matrix metalloproteinase 3 (stromelysin 1, progelatinase)
    • matrix metalloproteinase-3
    • MGC126102
    • MGC126103
    • MGC126104
    • MMP-3
    • proteoglycanase
    • SL-1
    • STMY
    • STMY1
    • STR1
    • stromelysin-1
    • transin-1
  • 基因序列：NCBI_Gene: 4314
  • 蛋白序列：UniProtKB: P08254

人 Human MMP3靶点分子功能（预测）

Enables endopeptidase activity and metallopeptidase activity. Involved in several processes, including cellular response to UV-A; negative regulation of hydrogen peroxide metabolic process; and positive regulation of protein-containing complex assembly. Predicted to be located in cytosol and mitochondrion. Implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Biomarker of several diseases, including Takayasu's arteritis; arthritis (multiple); autoimmune disease (multiple); conjunctivochalasis; and lung disease (multiple).

小鼠 Mouse Mmp3 分子靶点信息

小鼠 Mouse Mmp3 靶点分子功能（预测）

Predicted to enable metalloendopeptidase activity. Involved in several processes, including negative regulation of protein kinase B signaling; positive regulation of oxidative stress-induced cell death; and protein catabolic process. Acts upstream of or within cellular response to amino acid stimulus and regulation of cell migration. Located in cytosol and mitochondrion. Is expressed in several structures, including axial skeleton thoracic region; genitourinary system; liver; oral region epithelium; and palatal shelf. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).

大鼠 Rat Mmp3 分子靶点信息

大鼠 Rat Mmp3 靶点分子功能（预测）

Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Located in several cellular components, including cell body; dendrite; and extracellular space. Part of protein-containing complex. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).

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