MMP2 靶点信息

MMP2 分子靶点信息概述

  • 分子名：MMP2, matrix metallopeptidase 2
  • 基因家族：M10 matrix metallopeptidases
  • 别名：TBE-1
  • 曾用名：CLG4; CLG4A
  • 全称：matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

MMP2 分子靶点综述

基质金属蛋白酶2(MMP-2)，又名72kDa的IV型胶原酶和明胶酶A，在人类中由MMP2基因编码。激活MMP-2需要蛋白水解加工。MMP-2在子宫内膜破裂、调节血管形成和炎症应答中起作用。MMP-2参与许多事件，如癌症进程、癌细胞浸润、细胞信号转导、新血管形成和淋巴管生成。MMP2基因突变与Torg-Winchester综合征、多发性骨溶解、关节炎综合征有关，可能与瘢痕疙瘩有关。非囊性纤维化支气管扩张中，相比于呼吸道感染铜绿假单胞菌的患者，感染流感嗜血杆菌患者的MMP-2浓度是升高的。

MMP2, matrix metallopeptidase 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MMP2 分子靶点信息

  • 分子名：MMP2, matrix metallopeptidase 2
  • 别称：
    • 72 kDa gelatinase
    • 72 kDa type IV collagenase
    • CLG4
    • CLG4A
    • collagenase type IV-A
    • gelatinase A
    • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
    • matrix metalloproteinase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase)
    • matrix metalloproteinase-2
    • matrix metalloproteinase-II
    • MMP-2
    • MMP-II
    • MONA
    • neutrophil gelatinase
    • TBE-1
  • 基因序列：NCBI_Gene: 4313
  • 蛋白序列：UniProtKB: P08253

人 Human MMP2靶点分子功能（预测）

Enables metallopeptidase activity and serine-type endopeptidase activity. Involved in several processes, including cellular response to UV-A; endodermal cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Biomarker of several diseases, including artery disease (multiple); carcinoma (multiple); cardiomyopathy (multiple); cholesteatoma (multiple); and neurodegenerative disease (multiple).

小鼠 Mouse Mmp2 分子靶点信息

小鼠 Mouse Mmp2 靶点分子功能（预测）

Enables metalloendopeptidase activity. Involved in response to amyloid-beta. Acts upstream of or within several processes, including blood vessel maturation; bone trabecula formation; and collagen catabolic process. Located in several cellular components, including extracellular space; mitochondrion; and sarcomere. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; jaw; and musculoskeletal system. Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).

大鼠 Rat Mmp2 分子靶点信息

  • 分子名：Mmp2, matrix metallopeptidase 2
  • 别称：
    • 72 kDa gelatinase
    • 72 KDa type IV collagenase
    • gelatinase A
    • matrix metalloproteinase 2
    • matrix metalloproteinase 2 (72 KDa type IV collagenase)
    • matrix metalloproteinase-2
    • MMP-2
  • 基因序列：NCBI_Gene: 81686
  • 蛋白序列：

大鼠 Rat Mmp2 靶点分子功能（预测）

Enables fibronectin binding activity and peptidase activity. Involved in several processes, including cellular response to estradiol stimulus; circulatory system development; and reproductive structure development. Located in cytoplasm and extracellular space. Used to study artery disease (multiple); conjunctivitis; and transient cerebral ischemia. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); bile duct disease (multiple); brain ischemia (multiple); and liver cirrhosis (multiple). Human ortholog(s) of this gene implicated in artery disease (multiple); eye disease (multiple); pseudoxanthoma elasticum; and temporal arteritis. Orthologous to human MMP2 (matrix metallopeptidase 2).

MMP2 分子产品列表

MMP2 分子靶点最新资讯