MMP13 靶点信息

MMP13 分子靶点信息概述

  • 分子名：MMP13, matrix metallopeptidase 13
  • 基因家族：Receptor ligands; M10 matrix metallopeptidases
  • 别名：CLG3
  • 全称：collagenase 3; matrix metalloproteinase 13 (collagenase 3)

MMP13 分子靶点综述

基质金属蛋白酶(MMPs)是钙依赖性的含锌蛋白酶，其中有 26 个成员(MMP-1 至 MMP-26)已被确定。MMPs 参与正常生理过程(如胚胎发育、繁殖、组织重塑)和病理过程(如关节炎和转移)中细胞外基质的降解。MMP-13，又名胶原酶 3，在人类中由 MMP13 基因编码。与大多数 MMPs 一样，它以非活性的前体形式被分泌存在。前肽结构域一旦被裂解，MMP-13 就被激活，该活化酶由催化结构域和类血红素结构域 PDB: 1PEX 组成。在胚胎发育过程中，MMP-13 在骨骼中表达，对于骨矿化中胶原基质的重组是必不可少的。在病理情况下，如肿瘤、类风湿关节炎和骨关节炎，MMP-13 是高度过表达的。

MMP13, matrix metallopeptidase 13 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MMP13 分子靶点信息

  • 分子名：MMP13, matrix metallopeptidase 13
  • 别称：
    • CLG3
    • collagenase 3
    • MANDP1
    • matrix metallopeptidase 13 (collagenase 3)
    • matrix metalloproteinase 13 (collagenase 3)
    • MDST
    • MMP-13
  • 基因序列：NCBI_Gene: 4322
  • 蛋白序列：UniProtKB: P45452

人 Human MMP13靶点分子功能（预测）

Enables collagen binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in bone morphogenesis; collagen catabolic process; and extracellular matrix disassembly. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. Implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Biomarker of invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer.

小鼠 Mouse Mmp13 分子靶点信息

小鼠 Mouse Mmp13 靶点分子功能（预测）

Enables metalloendopeptidase activity. Involved in several processes, including bone mineralization; endochondral ossification; and extracellular matrix disassembly. Acts upstream of or within cellular protein metabolic process; collagen catabolic process; and growth plate cartilage development. Predicted to be located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Is expressed in several structures, including connective tissue; inner ear; jaw; limb mesenchyme; and skeletal system. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13).

大鼠 Rat Mmp13 分子靶点信息

  • 分子名：Mmp13, matrix metallopeptidase 13
  • 别称：
    • collagenase 3
    • collagenase-3
    • interstitial collagenase
    • matrix metalloproteinase 13
    • matrix metalloproteinase-13
    • MMP-13
    • UMRCASE
  • 基因序列：NCBI_Gene: 171052
  • 蛋白序列：

大鼠 Rat Mmp13 靶点分子功能（预测）

Enables several functions, including fibronectin binding activity; low-density lipoprotein particle receptor binding activity; and metal ion binding activity. Involved in several processes, including animal organ development; embryonic hindlimb morphogenesis; and estrous cycle. Located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Used to study brain ischemia; degenerative disc disease; and myocardial infarction. Biomarker of several diseases, including degenerative disc disease; gastric ulcer; liver cirrhosis (multiple); meningococcal meningitis; and silicosis. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13).

MMP13 分子产品列表

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