MMP1 靶点信息

MMP1 分子靶点信息概述

  • 分子名：MMP1, matrix metallopeptidase 1
  • 基因家族：Receptor ligands; M10 matrix metallopeptidases
  • 曾用名：CLG
  • 全称：interstitial collagenase; matrix metalloproteinase 1 (interstitial collagenase)

MMP1 分子靶点综述

基质金属蛋白酶1(MMP-1)，又名间质胶原酶和成纤维细胞胶原酶，在人类中由MMP1基因编码。MMP-1由成纤维细胞、软骨细胞、巨噬细胞、角质形成细胞、内皮细胞和成骨细胞产生。其产生受多种刺激物包括细胞因子(如EGF、白细胞介素和TNF-α)和化学物上调，受TIMP-1、TIMP-2和α2-巨球蛋白抑制。MMP-1在细胞外基质重塑中的胶原纤维降解中起重要作用，并参与多种生物过程包括类风湿性关节炎、骨关节炎、牙周病、肿瘤侵袭、血管形成、角膜溃疡、组织重塑、炎症性肠病、动脉粥样硬化和动脉瘤。另外，MMP-1同样也裂解多种底物如酪蛋白、明胶、蛋白聚糖、内功素、促肿瘤坏死因子和软骨连接蛋白。

MMP1, matrix metallopeptidase 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MMP1 分子靶点信息

  • 分子名：MMP1, matrix metallopeptidase 1
  • 别称：
    • CLG
    • CLGN
    • fibroblast collagenase
    • interstitial collagenase
    • matrix metallopeptidase 1 (interstitial collagenase)
    • matrix metalloprotease 1
    • matrix metalloproteinase 1
    • matrix metalloproteinase 1 (interstitial collagenase)
  • 基因序列：NCBI_Gene: 4312
  • 蛋白序列：UniProtKB: P03956

人 Human MMP1靶点分子功能（预测）

Enables metalloendopeptidase activity. Involved in cellular response to UV-A; positive regulation of protein-containing complex assembly; and proteolysis. Predicted to be located in extracellular region. Implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Biomarker of several diseases, including artery disease (multiple); arthritis (multiple); idiopathic pulmonary fibrosis; immunoglobulin light chain amyloidosis; and systemic lupus erythematosus.

小鼠 Mouse Mmp1a 分子靶点信息

小鼠 Mouse Mmp1a 靶点分子功能（预测）

Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Is expressed in several structures, including extraembryonic component and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1).

大鼠 Rat Mmp1 分子靶点信息

  • 分子名：Mmp1, matrix metallopeptidase 1
  • 别称：
    • Clgn
    • fibroblast collagenase
    • interstitial collagenase
    • LOC300339
    • matrix metallopeptidase 1 (interstitial collagenase)
    • matrix metallopeptidase 1a
    • matrix metallopeptidase 1a (interstitial collagenase)
    • matrix metalloproteinase 1
    • matrix metalloproteinase 1a (interstitial collagenase)
    • matrix metalloproteinase-1
    • MMP-1
    • Mmp1a
    • myocardial collagenase
  • 基因序列：NCBI_Gene: 300339
  • 蛋白序列：

大鼠 Rat Mmp1 靶点分子功能（预测）

Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in cytoplasm and extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1).

MMP1 分子产品列表

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