MKI67 靶点信息

MKI67 分子靶点信息概述

  • 分子名：MKI67, marker of proliferation Ki-67
  • 基因家族：Protein phosphatase 1 regulatory subunits
  • 别名：MIB-1; PPP1R105; Ki-67
  • 全称：protein phosphatase 1, regulatory subunit 105; Molecular Immunology Borstel antibody 1; antigen identified by monoclonal antibody Ki-67

MKI67 分子靶点综述

KI-67也称为Ki-67或MKI67，在人类中是一种由MKI67基因编码的蛋白质。Ki-67是350 - 400kDa的核蛋白，属于染色体有丝分裂相关蛋白的成员。此外，Ki-67与核糖体RNA转录有关，其失活会抑制核糖体RNA的合成。Ki-67与160kDa 的Hklp2相互作用，后者促进中心体分离和纺锤体的两极性。它也直接与NIFK相互作用，并结合UBF，从而在核糖体RNA的合成中发挥作用。在ER阳性乳腺癌患者中，Ki-67代表了一群高增殖性的亚群，使他们在辅助化疗中获益更多。

MKI67, marker of proliferation Ki-67 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MKI67 分子靶点信息

  • 分子名：MKI67, marker of proliferation Ki-67
  • 别称：
    • antigen identified by monoclonal antibody Ki-67
    • antigen KI-67
    • antigen Ki67
    • KIA
    • MIB-
    • MIB-1
    • Molecular Immunology Borstel antibody 1
    • PPP1R105
    • proliferation marker protein Ki-67
    • proliferation-related Ki-67 antigen
  • 基因序列：NCBI_Gene: 4288
  • 蛋白序列：UniProtKB: P46013

人 Human MKI67靶点分子功能（预测）

Enables protein C-terminus binding activity. Involved in regulation of chromosome segregation and regulation of mitotic nuclear division. Located in chromosome; nuclear body; and nucleolus. Colocalizes with condensed chromosome. Implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Biomarker of several diseases, including Barrett's esophagus; autoimmune disease of musculoskeletal system (multiple); endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and interstitial cystitis.

小鼠 Mouse Mki67 分子靶点信息

小鼠 Mouse Mki67 靶点分子功能（预测）

Predicted to enable protein C-terminus binding activity. Involved in regulation of chromatin organization. Acts upstream of or within cholangiocyte proliferation; hepatocyte proliferation; and meiotic cell cycle. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).

大鼠 Rat Mki67 分子靶点信息

  • 分子名：Mki67, marker of proliferation Ki-67
  • 别称：
    • antigen identified by monoclonal antibody Ki-67
    • antigen KI-67
    • LOC291234
    • proliferation marker protein Ki-67
  • 基因序列：NCBI_Gene: 291234
  • 蛋白序列：UniProtKB: D4A0Y6

大鼠 Rat Mki67 靶点分子功能（预测）

Predicted to enable protein C-terminus binding activity. Involved in several processes, including DNA metabolic process; animal organ regeneration; and cellular response to heat. Located in nucleus. Used to study high grade glioma; leiomyoma; and prostate carcinoma. Biomarker of colon cancer; kidney disease; mucositis; type 2 diabetes mellitus; and urinary bladder cancer. Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Orthologous to human MKI67 (marker of proliferation Ki-67).

MKI67 分子产品列表

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