MICB 靶点信息

MICB 分子靶点信息概述

  • 分子名：MICB, MHC class I polypeptide-related sequence B
  • 基因家族：C1-set domain containing
  • 别名：PERB11.2

MICB 分子靶点综述

MICB (人组织相容性复合体I类相关基因B) 作为人 NKG2D II 型受体的配体，是一种跨膜糖蛋白。MICB 基因位于人6号染色体的MHC-I类区域，具有多态性，有超过15个已知的人类等位基因。MICB 在正常细胞中仅微量表达，它通常表达在上皮性肿瘤中，并可被细菌和病毒感染诱导表达。因此，MICB 的识别与肿瘤监测，病毒感染和自身免疫性疾病的预防等密切有关。

MICB, MHC class I polypeptide-related sequence B 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MICB 分子靶点信息

  • 分子名：MICB, MHC class I polypeptide-related sequence B
  • 别称：
    • MHC class I antigen-related protein B
    • MHC class I chain-related protein B
    • MHC class I mic-B antigen
    • MHC class I-like molecule PERB11.2-IMX
    • MIC-B
    • PERB11.2
    • stress inducible class I homolog
  • 基因序列：NCBI_Gene: 4277
  • 蛋白序列：UniProtKB: Q29980

人 Human MICB靶点分子功能（预测）

Enables natural killer cell lectin-like receptor binding activity. Involved in several processes, including immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; and response to retinoic acid. Predicted to be located in cell surface. Predicted to be anchored component of external side of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space.

小鼠 Mouse Mill2 分子靶点信息

小鼠 Mouse Mill2 靶点分子功能（预测）

Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be involved in immune response. Is anchored component of external side of plasma membrane. Orthologous to human MICA (MHC class I polypeptide-related sequence A) and MICB (MHC class I polypeptide-related sequence B).

大鼠 Rat Micb 分子靶点信息

  • 分子名：Micb, MHC class I polypeptide-related sequence B
  • 别称：
    • MHC class I-like located near the leukocyte receptor complex 2
    • MHC class I-like located near the LRC, 2
    • MHC class I-like protein MILL2
    • MHC I like leukocyte 2
    • Mill2
    • Mill2 gene for MHC class I-like located near the LRC, 2, exon 3, partial cds, strain:LEW.1lm1
  • 基因序列：NCBI_Gene: 365212
  • 蛋白序列：

大鼠 Rat Micb 靶点分子功能（预测）

Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be involved in several processes, including immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; and response to retinoic acid. Predicted to be anchored component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to human MICB (MHC class I polypeptide-related sequence B).

MICB 分子产品列表

MICB 分子靶点最新资讯