MDK 靶点信息

MDK 分子靶点信息概述

  • 分子名：MDK, midkine
  • 别名：MK; FLJ27379
  • 曾用名：NEGF2
  • 全称：neurite growth-promoting factor 2

MDK 分子靶点综述

Midkine (MK或MDK)是一种 15 kDa的肝素结合分子，也被称为神经轴突生长促进因子2 (NEGF2)，是一种由MDK基因编码的蛋白。Midkine具有多效性，能发挥细胞增殖、细胞迁移、血管生成和 纤维蛋白溶解等作用。在多种癌症类型中如神经母细胞瘤、大肠癌、肝癌、卵巢癌等发现有Midkine的表达。这些恶性肿瘤患者的血清中 Midkine 浓度要比正常人高得多。在某些情况下，这些高浓度的 Midkine 也预示着疾病的预后较差，如神经母细胞瘤、胶质瘤和膀胱癌。Midkine 作为一种低亲和力的受体与细胞表面的核仁素结合。这种结合可以抑制艾滋病毒感染。

MDK, midkine 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human MDK 分子靶点信息

  • 分子名：MDK, midkine
  • 别称：
    • amphiregulin-associated protein
    • ARAP
    • FLJ27379
    • midgestation and kidney protein
    • midkine (neurite growth-promoting factor 2)
    • MK
    • NEGF2
    • neurite growth-promoting factor 2
    • neurite outgrowth-promoting factor 2
    • neurite outgrowth-promoting protein
    • retinoic acid inducible factor
  • 基因序列：NCBI_Gene: 4192
  • 蛋白序列：UniProtKB: P21741

人 Human MDK靶点分子功能（预测）

Enables heparan sulfate binding activity and heparin binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell migration; and regulation of leukocyte cell-cell adhesion. Colocalizes with collagen-containing extracellular matrix. Implicated in brain ischemia. Biomarker of endometriosis.

小鼠 Mouse Mdk 分子靶点信息

小鼠 Mouse Mdk 靶点分子功能（预测）

Enables chondroitin sulfate binding activity and heparin binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell adhesion; and positive regulation of leukocyte migration. Acts upstream of or within cerebral cortex development and dentate gyrus development. Predicted to be located in cell projection and cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).

大鼠 Rat Mdk 分子靶点信息

大鼠 Rat Mdk 靶点分子功能（预测）

Predicted to enable glycosaminoglycan binding activity and growth factor activity. Involved in several processes, including adrenal gland development; response to glucocorticoid; and response to wounding. Located in cell projection and cytoplasm. Used to study brain infarction and coronary stenosis. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).

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