LGALS3 靶点信息

LGALS3 分子靶点信息概述

  • 分子名：LGALS3, galectin 3
  • 基因家族：Receptor ligands; Galectins
  • 别名：MAC-2; GALIG
  • 曾用名：LGALS2
  • 全称：advanced glycation end-product receptor 3; lectin, galactoside-binding, soluble, 3

LGALS3 分子靶点综述

半乳糖凝集素-3(Galectin-3)属于凝集素家族，表达于胞核、胞质、线粒体、细胞表面和胞外。Galectin-3对β-半乳糖苷酶具有亲和力，并展示其抗细菌和真菌的活性。它参与很多生物学过程，如细胞黏附、细胞活化和趋化作用、细胞生长和分化、细胞周期以及凋亡等。基于其广泛的生物学功能，Galectin-3被认为与癌症、炎症和纤维化、心脏疾病、中风等有关。Galectin-3表达水平与各种类型的纤维化有关联。在肝脏纤维化、肾脏纤维化以及特发性肺纤维化(IPF)中，Galectin-3的表达上调。在急性失代偿性心力衰竭和慢性心力衰竭人群中，高表达的Galectin-3会导致更高的死亡风险。同时，Galectin-3被认为在肿瘤转移中具有重要作用。

LGALS3, galectin 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LGALS3 分子靶点信息

  • 分子名：LGALS3, galectin 3
  • 别称：
    • 35 kDa lectin
    • advanced glycation end-product receptor 3
    • carbohydrate-binding protein 35
    • CBP35
    • GAL3
    • galactose-specific lectin 3
    • GALBP
    • galectin-3
    • GALIG
    • IgE-binding protein
    • L31
    • laminin-binding protein
    • lectin L-29
    • lectin, galactose binding, soluble 3
    • lectin, galactoside binding soluble 3
    • lectin, galactoside-binding, soluble, 3
    • LGALS2
    • MAC-2 antigen
    • MAC2
  • 基因序列：NCBI_Gene: 3958
  • 蛋白序列：UniProtKB: P17931

人 Human LGALS3靶点分子功能（预测）

Enables several functions, including IgE binding activity; chemoattractant activity; and laminin binding activity. Involved in several processes, including leukocyte chemotaxis; positive regulation of protein localization to plasma membrane; and regulation of apoptotic process. Located in immunological synapse; mitochondrial inner membrane; and nucleus. Is active in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in asthma. Biomarker of aortic valve stenosis and liver cirrhosis.

小鼠 Mouse Lgals3 分子靶点信息

小鼠 Mouse Lgals3 靶点分子功能（预测）

Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; skeleton; and skin. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).

大鼠 Rat Lgals3 分子靶点信息

  • 分子名：Lgals3, galectin 3
  • 别称：
    • 35 kDa lectin
    • AGE-R3
    • carbohydrate-binding protein 35
    • CBP 35
    • CBP30
    • epsilon BP
    • gal-3
    • galactose-specific lectin 3
    • galectin-3
    • IgE binding protein
    • L-34
    • laminin-binding protein
    • lectin galactoside-binding soluble 3 protein
    • lectin L-29
    • lectin, galactose binding, soluble 3
    • lectin, galactoside-binding, soluble, 3
    • mac-2 antigen
    • MGC105387
  • 基因序列：NCBI_Gene: 83781
  • 蛋白序列：

大鼠 Rat Lgals3 靶点分子功能（预测）

Enables several functions, including Fc-gamma receptor I complex binding activity; IgE binding activity; and advanced glycation end-product receptor activity. Involved in several processes, including negative regulation of cell proliferation in bone marrow; positive regulation of angiogenesis; and positive regulation of serotonin secretion. Located in several cellular components, including cell surface; extracellular space; and nucleus. Biomarker of several diseases, including acute kidney failure; attention deficit hyperactivity disorder; brain ischemia; congestive heart failure; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3).

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