LEPR 靶点信息

LEPR 分子靶点信息概述

  • 分子名：LEPR, leptin receptor
  • 基因家族：CD molecules; Immunoglobulin like domain containing
  • 别名：OBR; CD295

LEPR 分子靶点综述

瘦素受体 (Leptin R)也称为OB-R或CD295，在人类中，由LEPR基因编码。它作为脂肪细胞特异性荷尔蒙瘦素的受体发挥作用。通过下丘脑对饥饿和能量消耗的作用，瘦素与其受体结合后调控脂肪组织块。瘦素受体的变异与糖尿病和对溶组织阿米巴感染易感性升高有关。

LEPR, leptin receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LEPR 分子靶点信息

  • 分子名：LEPR, leptin receptor
  • 别称：
    • CD295
    • DKFZp686B1731
    • huB219
    • LEP-R
    • LEPRD
    • OB receptor
    • OB-R
    • OBR
  • 基因序列：NCBI_Gene: 3953
  • 蛋白序列：UniProtKB: P48357

人 Human LEPR靶点分子功能（预测）

Enables identical protein binding activity and leptin receptor activity. Involved in several processes, including angiogenesis; leptin-mediated signaling pathway; and negative regulation of autophagy. Part of receptor complex. Implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Biomarker of arteriosclerosis; chronic obstructive pulmonary disease; human immunodeficiency virus infectious disease; liver disease (multiple); and sleep apnea.

小鼠 Mouse Lepr 分子靶点信息

小鼠 Mouse Lepr 靶点分子功能（预测）

Enables leptin receptor activity. Involved in several processes, including energy homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).

大鼠 Rat Lepr 分子靶点信息

大鼠 Rat Lepr 靶点分子功能（预测）

Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of locomotor rhythm; and positive regulation of cell communication. Located in extracellular space and plasma membrane. Used to study several diseases, including chronic kidney disease; glucose metabolism disease (multiple); obesity; pancreatitis; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).

LEPR 分子产品列表

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