LDLR 靶点信息

LDLR 分子靶点信息概述

  • 分子名：LDLR, low density lipoprotein receptor
  • 基因家族：Low density lipoprotein receptors; MicroRNA protein coding host genes
  • 别名：LDLCQ2
  • 全称：familial hypercholesterolemia

LDLR 分子靶点综述

低密度脂蛋白(LDL)受体(LDLR)是一个由839个氨基酸组成的嵌合蛋白，属于LDLR基因家族。它是一种细胞表面受体，可识别嵌入在LDL颗粒外磷脂层上的ApoB100，还可识别存在于乳糜微粒残余物和VLDL残余物中的ApoE蛋白。LDLR介导富含胆固醇的LDL的内吞作用。LDLR复合物存在于细胞表面的网格蛋白包被小窝(或芽)，后者通过衔接蛋白结合LDL-胆固醇，去组装形成网格蛋白包被的内体囊泡，这使LDL-胆固醇在内吞作用过程中发生内在化，还可防止LDL扩散在膜表面。上述过程发生在所有有核细胞中，但是主要发生在肝脏中，通过循环可去除约70%的LDL。上调LDLR导致血脂下降，这可能与甲状腺机能亢进有关，而甲状腺机能减退却相反。

LDLR, low density lipoprotein receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LDLR 分子靶点信息

  • 分子名：LDLR, low density lipoprotein receptor
  • 别称：
    • FH
    • FHC
    • FHCL1
    • LDL receptor
    • LDLCQ2
    • low-density lipoprotein receptor
    • low-density lipoprotein receptor class A domain-containing protein 3
  • 基因序列：NCBI_Gene: 3949
  • 蛋白序列：UniProtKB: P01130

人 Human LDLR靶点分子功能（预测）

Enables several functions, including low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and very-low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; cholesterol transport; and long-term memory. Located in several cellular components, including clathrin-coated pit; endosome; and external side of plasma membrane. Part of PCSK9-LDLR complex and receptor complex. Implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Biomarker of systemic lupus erythematosus.

小鼠 Mouse Ldlr 分子靶点信息

小鼠 Mouse Ldlr 靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and sensory organ. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).

大鼠 Rat Ldlr 分子靶点信息

大鼠 Rat Ldlr 靶点分子功能（预测）

Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study atherosclerosis and xanthomatosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).

LDLR 分子产品列表

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