LCN2 靶点信息

LCN2 分子靶点信息概述

  • 分子名：LCN2, lipocalin 2
  • 基因家族：Lipocalins
  • 别名：NGAL; 24p3
  • 全称：oncogene 24p3; neutrophil gelatinase-associated lipocalin; siderocalin; lipocalin 2 (oncogene 24p3)

LCN2 分子靶点综述

脂质运载蛋白2，又名中性粒细胞明胶酶相关的脂质运载蛋白(NGAL)或癌基因24p3，在中性粒细胞中表达，在肾脏、前列腺、呼吸道和消化道的上皮细胞中低表达。Lipocalin-2通过螯合铁来参与先天性免疫，反过来可限制细菌的生长。Lipocalin-2是肾损伤的生物标志物，还可作为慢性肾脏病、造影剂肾病和肾移植的早期诊断物。在急性肾损伤(AKI)的2小时内，高水平的Lipocalin-2被分泌到血液和尿中。机体的Lipocalin-2水平与AKI的严重程度成正比。

LCN2, lipocalin 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LCN2 分子靶点信息

  • 分子名：LCN2, lipocalin 2
  • 别称：
    • 24p3
    • 25 kDa alpha-2-microglobulin-related subunit of MMP-9
    • lipocalin-2
    • migration-stimulating factor inhibitor
    • MSFI
    • neutrophil gelatinase-associated lipocalin
    • NGAL
    • oncogene 24p3
    • p25
    • siderocalin
    • siderocalin LCN2
  • 基因序列：NCBI_Gene: 3934
  • 蛋白序列：UniProtKB: P80188

人 Human LCN2靶点分子功能（预测）

Enables enterobactin binding activity; identical protein binding activity; and iron ion binding activity. Involved in defense response to bacterium and sequestering of iron ion. Located in extracellular space. Implicated in urinary tract infection. Biomarker of several diseases, including congenital diaphragmatic hernia; hidradenitis suppurativa; hydronephrosis; hypertension (multiple); and kidney disease (multiple).

小鼠 Mouse Lcn2 分子靶点信息

小鼠 Mouse Lcn2 靶点分子功能（预测）

Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2).

大鼠 Rat Lcn2 分子靶点信息

  • 分子名：Lcn2, lipocalin 2
  • 别称：
    • alpha-2-microglobulin-related protein
    • alpha-2U globulin-related protein
    • lipocalin 2 (oncogene 24p3)
    • lipocalin 24p3
    • lipocalin-2
    • neutrophil gelatinase-associated lipocalin
    • NGAL
    • p25
    • siderocalin LCN2
    • Sip24
  • 基因序列：NCBI_Gene: 170496
  • 蛋白序列：UniProtKB: P30152

大鼠 Rat Lcn2 靶点分子功能（预测）

Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of neuron apoptotic process. Located in cytosol and extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; pulmonary hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in urinary tract infection. Orthologous to human LCN2 (lipocalin 2).

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