LAMP1 靶点信息

CD107/LAMP1 分子靶点信息概述

  • 分子名：LAMP1, lysosomal associated membrane protein 1
  • 基因家族：Lysosome associated membrane proteins; CD molecules
  • 别名：CD107a; lysosomal-associated membrane protein 1
  • 全称：lysosomal associated membrane protein 1

LAMP1/CD107a 分子靶点综述

CD107a，也称为溶酶体相关膜蛋白1（LAMP-1）或LGP-120，是一种110-140kD的I型膜糖蛋白。活化后的CD107a转移到活化的血小板、活化的淋巴细胞、巨噬细胞、上皮细胞、内皮细胞和一些肿瘤细胞的细胞膜表面。CD107a被认为在保护溶酶体膜免受溶酶体水解酶的影响中发挥作用，溶酶体水解酶参与细胞粘附和肿瘤转移的调节，并介导自身免疫性疾病的进展。CD107a是半乳肽和E-选择素的配体。LAMP-1的表达已被证明与CD8+T细胞和NK细胞的细胞毒性相关。

LAMP1, lysosomal associated membrane protein 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human LAMP1 分子靶点信息

  • 分子名：LAMP1, lysosomal associated membrane protein 1
  • 别称：
    • CD107 antigen-like family member A
    • CD107a
    • LAMP-1
    • LAMPA
    • LGP120
    • lysosomal membrane glycoprotein 1
    • lysosomal-associated membrane protein 1
    • lysosome-associated membrane glycoprotein 1
    • lysosome-associated membrane protein 1
  • 基因序列：NCBI_Gene: 3916
  • 蛋白序列：UniProtKB: P11279

人 Human LAMP1靶点分子功能（预测）

Enables enzyme binding activity. Involved in several processes, including Golgi to lysosome transport; granzyme-mediated programmed cell death signaling pathway; and positive regulation of natural killer cell degranulation. Located in several cellular components, including cytolytic granule membrane; late endosome; and perinuclear region of cytoplasm. Colocalizes with lysosome.

小鼠 Mouse Lamp1 分子靶点信息

小鼠 Mouse Lamp1 靶点分子功能（预测）

Enables protein domain specific binding activity. Involved in protein stabilization. Located in several cellular components, including cytoplasmic vesicle; sarcolemma; and vacuole. Is expressed in several structures, including central nervous system; craniocervical region bone; extraembryonic component; gut; and sensory organ. Orthologous to human LAMP1 (lysosomal associated membrane protein 1).

大鼠 Rat Lamp1 分子靶点信息

  • 分子名：Lamp1, lysosomal-associated membrane protein 1
  • 别称：
    • 120 kDa lysosomal membrane glycoprotein
    • CD107 antigen-like family member A
    • LAMP-1
    • LGP-120
    • LGP120
    • Lysosomal associated membrane protein 1 (120 kDa)
    • lysosomal membrane glycoprotein 1
    • lysosome-associated membrane glycoprotein 1
    • lysosome-associated membrane protein 1
  • 基因序列：NCBI_Gene: 25328
  • 蛋白序列：

大鼠 Rat Lamp1 靶点分子功能（预测）

Predicted to enable enzyme binding activity and protein domain specific binding activity. Involved in autophagic cell death. Located in several cellular components, including cytoplasmic vesicle; lysosome; and neuronal cell body. Orthologous to human LAMP1 (lysosomal associated membrane protein 1).

LAMP1 分子产品列表

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