KITLG 靶点信息

KITLG 分子靶点信息概述

  • 分子名：KITLG, KIT ligand
  • 别名：SCF; SF; Kitl; KL-1; FPH2; SLF; DFNA69
  • 曾用名：MGF
  • 全称：mast cell growth factor; stem cell factor; steel factor; familial progressive hyperpigmentation 2

KITLG 分子靶点综述

干细胞因子(SCF)是一个可结合到c-Kit受体上的细胞因子，它可作为跨膜蛋白和可溶性蛋白存在。SCF促进肥大细胞粘附、迁移、增殖和存活，同样也可促进组胺和类胰蛋白酶的释放，后两者参与过敏应答。SCF与多种生长因子如IL-3、IL-6、IL-11、GM-CSF、G-CSF和Epo协同作用，一起诱导髓系和红系集落形成。该细胞因子在造血(血细胞生成)、精子发生和黑素生成中起重要作用。心肌特异性过表达跨膜SCF会促进干细胞迁移、提高心肌梗死后的心脏功能和动物的存活率。狗的SCF基因突变表明该基因是皮肤癌的候选易感基因。

KITLG, KIT ligand 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human KITLG 分子靶点信息

  • 分子名：KITLG, KIT ligand
  • 别称：
    • c-Kit ligand
    • DCUA
    • DFNA69
    • DKFZp686F2250
    • familial progressive hyperpigmentation 2
    • FPH2
    • FPHH
    • kit-ligand
    • Kitl
    • KL-1
    • mast cell growth factor
    • MGF
    • SCF
    • SF
    • SHEP7
    • SLF
    • steel factor
    • stem cell factor
  • 基因序列：NCBI_Gene: 4254
  • 蛋白序列：UniProtKB: P21583

人 Human KITLG靶点分子功能（预测）

Predicted to enable cytokine activity and stem cell factor receptor binding activity. Involved in embryonic hemopoiesis; male gonad development; and positive regulation of cell population proliferation. Located in several cellular components, including filopodium; lamellipodium; and plasma membrane. Implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation.

小鼠 Mouse Kitl 分子靶点信息

小鼠 Mouse Kitl 靶点分子功能（预测）

Enables cytokine activity and stem cell factor receptor binding activity. Acts upstream of or within several processes, including positive regulation of cell differentiation; positive regulation of cell population proliferation; and positive regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Is integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).

大鼠 Rat Kitlg 分子靶点信息

  • 分子名：Kitlg, KIT ligand
  • 别称：
    • C-kit ligand
    • hematopoietic growth factor KL
    • Kitl
    • Kl1
    • Kl2
    • LOC60427
    • LOC60428
    • mast cell growth factor
    • Mgf
    • SCF
    • steel factor/kit ligand
    • stem cell factor
    • stem cell factor KL-1
    • stem cell factor KL-1 precursor
    • stem cell factor KL-2 precursor
  • 基因序列：NCBI_Gene: 60427
  • 蛋白序列：

大鼠 Rat Kitlg 靶点分子功能（预测）

Predicted to enable cytokine activity and stem cell factor receptor binding activity. Involved in ovarian follicle development and positive regulation of cell population proliferation. Predicted to be located in several cellular components, including extracellular space; filopodium; and lamellipodium. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 69 and familial progressive hyperpigmentation with or without hypopigmentation. Orthologous to human KITLG (KIT ligand).

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