ITGA2 靶点信息

ITGA2 分子靶点信息概述

  • 分子名：ITGA2, integrin subunit alpha 2
  • 基因家族：CD molecules; Integrin alpha subunits
  • 别名：CD49b
  • 曾用名：CD49B
  • 全称：alpha 2 subunit of VLA-2 receptor; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

ITGA2 分子靶点综述

CD49b，也称为整合素α2，是一种150 kD膜表面糖蛋白。CD49b (整合素α2)与CD29 (整合素β1)非共价结合形成异质二聚体VLA-2即血小板糖蛋白Ia/IIa (CD49b/CD29)，可介导成熟巨核细胞和血小板与胶原之间的粘附。CD49b表达于血小板、肠上皮细胞、NK细胞、上皮细胞和活化T细胞等，在介导胞外基质细胞粘附中起着重要作用。

ITGA2, integrin subunit alpha 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ITGA2 分子靶点信息

  • 分子名：ITGA2, integrin subunit alpha 2
  • 别称：
    • alpha 2 subunit of VLA-2 receptor
    • BDPLT9
    • BR
    • CD49 antigen-like family member B
    • CD49B
    • collagen receptor
    • GPIa
    • HPA-5
    • human platelet alloantigen system 5
    • integrin alpha 2
    • integrin alpha-2
    • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
    • platelet antigen Br
    • platelet glycoprotein GPIa
    • platelet glycoprotein Ia
    • platelet membrane glycoprotein Ia
    • very late activation protein 2 receptor, alpha-2 subunit
    • VLA-2
    • VLA-2 subunit alpha
    • VLA2 receptor, alpha-2 subunit
    • VLAA2
  • 基因序列：NCBI_Gene: 3673
  • 蛋白序列：UniProtKB: P17301

人 Human ITGA2靶点分子功能（预测）

Enables collagen binding activity involved in cell-matrix adhesion and collagen receptor activity. Involved in several processes, including cell adhesion mediated by integrin; cell surface receptor signaling pathway; and mesodermal cell differentiation. Located in cell surface; focal adhesion; and plasma membrane. Part of integrin alpha2-beta1 complex. Implicated in several diseases, including Behcet's disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Biomarker of type 2 diabetes mellitus.

小鼠 Mouse Itga2 分子靶点信息

小鼠 Mouse Itga2 靶点分子功能（预测）

Enables amyloid-beta binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell migration; and positive regulation of cellular component organization. Predicted to act upstream of or within cell adhesion. Located in basal part of cell and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2).

大鼠 Rat Itga2 分子靶点信息

  • 分子名：Itga2, integrin subunit alpha 2
  • 别称：
    • CD49B
    • GPIa
    • HPA-5
    • integrin alpha 2
    • integrin alpha-2
    • integrin, alpha 2
    • platelet glycoprotein Ia
  • 基因序列：NCBI_Gene: 170921
  • 蛋白序列：UniProtKB: A0A0G2K470

大鼠 Rat Itga2 靶点分子功能（预测）

Enables collagen binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including gland development; positive regulation of cell migration; and positive regulation of cellular component organization. Located in several cellular components, including axon terminus; focal adhesion; and perinuclear region of cytoplasm. Biomarker of placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; artery disease (multiple); blood platelet disease (multiple); diabetes mellitus (multiple); and von Willebrand's disease (multiple). Orthologous to human ITGA2 (integrin subunit alpha 2).

ITGA2 分子产品列表

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