IL7R 靶点信息

IL7R 分子靶点信息概述

  • 分子名：IL7R, interleukin 7 receptor
  • 基因家族：CD molecules; Fibronectin type III domain containing; Interleukin receptors
  • 别名：CD127; IL7RA

IL7R 分子靶点综述

CD127是白细胞介素7受体α链，与CD132 (β链)共同形成高亲和力的受体。CD127表达于大部分T细胞，但在T细胞活化后可发生降低，也表达在B细胞前体和单核细胞。CD127的表达对T淋巴细胞的成熟、维持及免疫应答发挥着重要作用。

IL7R, interleukin 7 receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL7R 分子靶点信息

  • 分子名：IL7R, interleukin 7 receptor
  • 别称：
    • CD127
    • CD127 antigen
    • CDW127
    • IL-7 receptor subunit alpha
    • IL-7R subunit alpha
    • IL-7R-alpha
    • IL-7RA
    • IL7RA
    • ILRA
    • interleukin 7 receptor alpha chain
    • interleukin 7 receptor isoform H5-6
    • interleukin-7 receptor subunit alpha
  • 基因序列：NCBI_Gene: 3575
  • 蛋白序列：UniProtKB: P16871

人 Human IL7R靶点分子功能（预测）

Enables cytokine receptor activity. Involved in positive regulation of cell population proliferation and positive regulation of receptor signaling pathway via STAT. Located in cytosol; nucleoplasm; and plasma membrane. Implicated in severe combined immunodeficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.

小鼠 Mouse Il7r 分子靶点信息

小鼠 Mouse Il7r 靶点分子功能（预测）

Predicted to enable cytokine receptor activity. Involved in defense response to Gram-positive bacterium. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of T cell mediated cytotoxicity; and positive regulation of T cell differentiation in thymus. Located in external side of plasma membrane. Is expressed in adrenal gland; brain; early conceptus; hemolymphoid system; and lymphatic system. Human ortholog(s) of this gene implicated in severe combined immunodeficiency and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human IL7R (interleukin 7 receptor).

大鼠 Rat Il7r 分子靶点信息

大鼠 Rat Il7r 靶点分子功能（预测）

ENCODES a protein that exhibits cytokine receptor activity (ortholog); INVOLVED IN B cell proliferation (ortholog); cell morphogenesis (ortholog); defense response to Gram-positive bacterium (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; primary immunodeficiency pathway; ASSOCIATED WITH Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); COVID-19 (ortholog); endometriosis (ortholog); FOUND IN cytosol (ortholog); external side of plasma membrane (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate

IL7R 分子产品列表

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